Methyl 4-chloro-2-(N-methyl-N-phenylsulphonamide)benzoate

Base Information

• Chemical Name: Methyl 4-chloro-2-(N-methyl-N-phenylsulphonamide)benzoate
• CAS No.: 914221-64-0
• Molecular Formula: C₁₅H₁₄ClNO₄S
• Molecular Weight: 339.799
• Hs Code.: 2935009090
• Mol file: 914221-64-0.mol

Synonyms:Methyl 4-chloro-2-(N-methyl-N-phenylsulphonamide)benzoate;

Chemical Property of Methyl 4-chloro-2-(N-methyl-N-phenylsulphonamide)benzoate

Chemical Property:

• Vapor Pressure: 2.02E-09mmHg at 25°C
• Refractive Index: 1.602
• Boiling Point: 481.3 °C at 760 mmHg
• Flash Point: 244.9 °C
• PSA: 72.06000
• Density: 1.376 g/cm³
• LogP: 4.03250
• Storage Temp.: 2-8°C

Purity/Quality:

99%+, ^*data from raw suppliers

4-Chloro-2-(methyl-phenyl-sulfamoyl)-benzoic acid methylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-chloro-2-(N-methyl-N-phenylsulphonamide)benzoate

There total 2 articles about Methyl 4-chloro-2-(N-methyl-N-phenylsulphonamide)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.7%

N-methylaniline (100-61-8) + 4-chloro-2-chlorosulfonylbenzoic acid methyl ester (85392-01-4) → 4-chloro-2-(N-methyl-N-phenylaminesulfonyl)benzoic acid methyl ester (914221-64-0)

Guidance literature:

With pyridine; In dichloromethane; water; for 4h; Reflux;

Reference yield:

2-Amino-4-chlorobenzoic acid (89-77-0) → 4-chloro-2-(N-methyl-N-phenylaminesulfonyl)benzoic acid methyl ester (914221-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 14 h / 20 °C / Cooling with ice; Reflux

2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C

2.2: 1 h / 5 - 10 °C

3.1: pyridine / water; dichloromethane / 4 h / Reflux

With pyridine; hydrogenchloride; thionyl chloride; sodium nitrite; In dichloromethane; water;

upstream raw materials:

N-methylaniline

4-chloro-2-chlorosulfonylbenzoic acid methyl ester

2-Amino-4-chlorobenzoic acid

Refernces