6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridine
• CAS No.: 88965-00-8
• Molecular Formula: C15H14 N2
• Molecular Weight: 222.29
• Hs Code.: 2933990090
• European Community (EC) Number: 618-225-3
• DSSTox Substance ID: DTXSID00349880
• Nikkaji Number: J3.289.657J
• Wikidata: Q72492952
• ChEMBL ID: CHEMBL1440422
• Mol file: 88965-00-8.mol

Synonyms:88965-00-8;6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridine;6-Methyl-2-(p-tolyl)imidazo[1,2-a]pyridine;6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine;MFCD00444739;6-methyl-2-p-tolylimidazo[1,2-a]pyridine;BAS 03308107;MLS000707291;SCHEMBL396368;6-methyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine;CHEMBL1440422;DTXSID00349880;6-methyl-2-(4-methylphenyl)-4-hydroimidazo[1,2-a]pyridine;HMS2715J04;AMY38905;STK702061;AKOS000527449;AB05980;AC-6594;CCG-239353;DS-18359;SMR000288756;SY109614;6-methyl-2-p-tolylimidazo[1,2-a]pyridin;CS-0172131;FT-0653831;2-(p-Tolyl)-6-methylimidazo[1,2-a]pyridine;6-methyl-2-p-tolylH-imidazo[1,2-a]pyridine;2-(4-methylphenyl)-6-methylimidazo[1,2-a]-pyridine;6-Methyl-2-(4-methylphenyl)imidazo1,2-alphapyridine;BRD-K71668435-001-10-7;Z55863282;6-Methyl-2-(4-methylphenyl)-imidazo[1,2-a]-pyridine;6-Methyl-2-(4-methylphenyl)imidazo [1,2-alpha]pyridine;F0916-3171;imidazo[1,2-a]pyridine, 6-methyl-2-(4-methylphenyl)-

Chemical Property of 6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridine

Chemical Property:

• PKA: 7.07±0.50(Predicted)
• PSA: 17.30000
• Density: 1.09g/cm3
• LogP: 3.61810
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 222.115698455
• Heavy Atom Count: 17
• Complexity: 258

Purity/Quality:

99.9% ^*data from raw suppliers

6-Methyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=CN3C=C(C=CC3=N2)C
• Uses: 6-Methyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine is an impurity of Zolpidem (Z650000), a selective non-benzodiazepine GABAA receptor agonist.

Technology Process of 6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridine

There total 6 articles about 6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + 4-(bromoacetyl)toluene (619-41-0) → 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine (88965-00-8)

Guidance literature:

Reference yield: 90.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + p-methylphenacyl chloride (4209-24-9) → 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine (88965-00-8)

Guidance literature:

(5-methyl-pyridin-2-yl)amine; p-methylphenacyl chloride; With sodium hydrogencarbonate; In chloroform; at 60 ℃; for 4h; Heating / reflux;

With water; In chloroform; for 0.5h; Heating / reflux;

Reference yield: 83.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + para-methylacetophenone (122-00-9) → 6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine (88965-00-8)

Guidance literature:

With indium(III) triflate; copper(l) iodide; oxygen; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 30h; under 760.051 Torr; Schlenk technique;

DOI:10.1021/jo402134x

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

4-(bromoacetyl)toluene

p-methylphenacyl chloride

4-n-methylphenylacetylene

Downstream raw materials:

dimethyl-(6-methyl-2-p-tolylimidazo[1,2-a]pyridin-3-ylmethyl)-amine

6-methyl-3-cyanomethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine

ethyl 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetate

3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine

Refernces

• 1、 -. "Synthetic method of imidazopyridine compounds". Paragraph 0056; 0069-0071. . Retrieved 2021/03/24.
• 2、 Fajkis, Nikola,Gryzlo, Beata,Kolaczkowski, Marcin,Krupa, Anna,Marcinkowska, Monika. "Study on a three-step rapid assembly of zolpidem and its fluorinated analogues employing microwave-assisted chemistry". . . Retrieved 2020/08/24.