(R,S,S,S)-nebivolol hydrochloride

Base Information Edit

Chemical Name:(R,S,S,S)-nebivolol hydrochloride
CAS No.:169293-50-9
Molecular Formula:C₂₂H₂₅F₂NO₄*ClH
Molecular Weight:441.903
Hs Code.:
European Community (EC) Number:638-982-3,690-990-6
ChEMBL ID:CHEMBL2358570
DSSTox Substance ID:DTXSID1049065
NCI Thesaurus Code:C81656
RXCUI:236883
Mol file:169293-50-9.mol

Synonyms:67555, R;alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol;Bystolic;Hydrochloride, Nebivolol;Lobivon;Nebilet;nebivolol;nebivolol hydrochloride;R 67555;R-67555;R67555;Silostar

Suppliers and Price of (R,S,S,S)-nebivolol hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
racNebivololHydrochloride
250mg
$ 800.00

TRC
racNebivololHydrochloride
100mg
$ 405.00

TRC
racNebivololHydrochloride
50mg
$ 240.00

Matrix Scientific
2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol) hydrochloride 95+%
250mg
$ 1286.00

Crysdot
2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)hydrochloride 95+%
1g
$ 1345.00

Chemenu
2,2''-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)hydrochloride 95%
1g
$ 1267.00

Alichem
2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)hydrochloride
1g
$ 1196.80

AK Scientific
2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)hydrochloride
250mg
$ 1786.00

Total 33 raw suppliers

Chemical Property of (R,S,S,S)-nebivolol hydrochloride Edit

Chemical Property:

Appearance/Colour:White to off-white powder
Vapor Pressure:2.88E-15mmHg at 25°C
Melting Point:220-222 °C
Boiling Point:600.5 °C at 760 mmHg
Flash Point:316.9 °C
PSA：70.95000
LogP:3.55650
Storage Temp.:-20°C Freezer
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:441.1518423
Heavy Atom Count:30
Complexity:483

Purity/Quality:

99% ^*data from raw suppliers

racNebivololHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O.Cl
Isomeric SMILES:C1CC2=C(C=CC(=C2)F)O[C@H]1[C@H](CNC[C@@H]([C@@H]3CCC4=C(O3)C=CC(=C4)F)O)O.Cl
Recent ClinicalTrials:Treatment of Supine Hypertension in Autonomic Failure
Recent EU Clinical Trials:A multicentre randomised, double blind, active controlled, parallel group comparison of Nebivolol plus HCTZ and Irbesartan plus HCTZ in the treatment of isolated systolic hypertension in elderly patients.
Uses Nebivolol hydrochloride is a β1-Adrenergic blocker. Used as an antihypertensive.

Technology Process of (R,S,S,S)-nebivolol hydrochloride

There total 4 articles about (R,S,S,S)-nebivolol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 929706-85-4
N-benzylnebivolol

: 169293-50-9,152520-56-4,920299-33-8
nebivolol hydrochloride

Guidance literature:: N-benzylnebivolol; With 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; In water; for 12h; Large scale;

With sodium chloride; In water; for 8h; Large scale;