5-Nitropyridine-2-carboxylic acid

Base Information

• Chemical Name: 5-Nitropyridine-2-carboxylic acid
• CAS No.: 30651-24-2
• Molecular Formula: C6H4N2O4
• Molecular Weight: 168.109
• Hs Code.: 29333990
• Mol file: 30651-24-2.mol

Synonyms:Picolinicacid, 5-nitro- (6CI,8CI);5-Nitro-2-pyridinecarboxylic acid;5-Nitropicolinicacid;

Chemical Property of 5-Nitropyridine-2-carboxylic acid

Chemical Property:

• Appearance/Colour: Light Yellow Solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 218-220 °C
• Refractive Index: 1.625
• Boiling Point: 389.829 °C at 760 mmHg
• PKA: 2.71±0.13(Predicted)
• Flash Point: 189.562 °C
• PSA: 96.01000
• Density: 1.571 g/cm³
• LogP: 1.21120
• Storage Temp.: -20°C Freezer
• Solubility.: Soluble in dimethyl sulfoxide.

Purity/Quality:

99% ^*data from raw suppliers

5-Nitro-2-picolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-20/21/22
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Nitropyridine-2-carboxylic acid is a useful synthetic intermediate. It plays an important role in synthetic intermediate.

Technology Process of 5-Nitropyridine-2-carboxylic acid

There total 1 articles about 5-Nitropyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-methyl-5-nitropyridine (21203-68-9) → 5-nitropicolinic acid (30651-24-2)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; Ambient temperature;

DOI:10.1021/jo00194a002

Reference yield: 90.0%

5-nitropicolinic acid (30651-24-2) + 2-(1-cyclohexenyl)ethylamine (3399-73-3) → N-(2-(cyclohex-1-en-1-yl)ethyl)-5-nitropicolinamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02458

Reference yield: 88.0%

5-nitropicolinic acid (30651-24-2) + 2-fluoro-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)methyl]benzenamine → N-{2-fluoro-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)methyl]phenyl}-5-nitropyridine-2-carboxamide

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 2h; Alkaline conditions;

DOI:10.1134/S1070363220070208

upstream raw materials:

2-methyl-5-nitropyridine

Downstream raw materials:

5-amino-pyridine-2-carboxylic acid

ethyl 5-nitropyridine-2-carboxylate

5-Hydroxylaminopyridin-2-carbonsaeure

5-nitro-pyridine-2-carboxylic acid methyl ester

Refernces

• 1、 Schneider,Harris. "Synthesis of DL-slaframine". . p. 3681 - 3684. Retrieved 2007/10/02.