Cathine

Base Information Edit

Chemical Name:Cathine
CAS No.:37577-28-9
Deprecated CAS:16960-27-3,1926-74-5,27818-48-0,6891-23-2,54680-46-5
Molecular Formula:C9H13NO
Molecular Weight:151.208
Hs Code.:2922199090
European Community (EC) Number:207-754-1,253-014-6,628-077-1
UNII:27A0HLC3HH,E1L4ZW2F8O
DSSTox Substance ID:DTXSID20889399,DTXSID50889347
Nikkaji Number:J9.386F
Wikipedia:Cathine
Wikidata:Q423797
NCI Thesaurus Code:C79914
Metabolomics Workbench ID:68839
ChEMBL ID:CHEMBL1412041
Mol file:37577-28-9.mol

Synonyms:(+)-norpseudoephedrine;benzenemethanol, alpha-((1R)-1-aminoethyl)-, (alphaR)-rel-;cathine;cathine hydrochloride;exponcit;fasupond;Fugoa Depot;norpseudoephedrine;norpseudoephedrine hydrobromide;norpseudoephedrine hydrochloride;norpseudoephedrine hydrochloride, (+)-isomer;norpseudoephedrine hydrochloride, (R*,S*)-(+-)-isomer;norpseudoephedrine hydrochloride, (R*,S*)-isomer;norpseudoephedrine hydrochloride, (R-(R*,R*))-isomer;norpseudoephedrine hydrochloride, (S-(R*,S*))-isomer;norpseudoephedrine sulfate (2:1), (+)-isomer;norpseudoephedrine sulfate (2:1), (R-(R*,R*))-isomer;norpseudoephedrine sulfate, (R-(R*,S*))-isomer;norpseudoephedrine sulfate, (S-(R*,R*))-isomer;norpseudoephedrine tartrate, (S-(R*,R*))-(R-(R*,R*))-isomer;norpseudoephedrine, (-)-isomer;norpseudoephedrine, (R*,R*)-(+-)-isomer;norpseudoephedrine, (R*,S*)-isomer;norpseudoephedrine, (R-(R*,S*))-isomer;norpseudoephedrine, (S-(R*,R*))-isomer;norpseudoephedrine, (S-(R*,S*))-isomer;norpseudoephedrine, conjugate monoacid, (R-(R*,S*))-isomer;pseudonorephedrine

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Cathine Edit

Chemical Property:

Vapor Pressure:0.0011mmHg at 25°C
Melting Point:51-54 °C
Boiling Point:288.1 °C at 760 mmHg
PKA:12.07±0.45(Predicted)
Flash Point:128.1 °C
PSA：46.25000
Density:1.071g/cm³
LogP:1.76750
Storage Temp.:2-8°C
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:151.099714038
Heavy Atom Count:11
Complexity:110

Purity/Quality:

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(C1=CC=CC=C1)O)N
Isomeric SMILES:C[C@@H]([C@H](C1=CC=CC=C1)O)N
Recent EU Clinical Trials:A multicentre double blind placebo controlled clinical trial to assess efficacy and safety of Alvalin? (cathine hydrochloride) vs. placebo in 265 obese patients/group with a body mass index (BMI) between 30 and 45 kg/m2

Technology Process of Cathine

There total 50 articles about Cathine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 88196-06-9
(1S,2S)-1-phenyl-1,2-propanediol

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

Guidance literature:: With pyridoxal 5'-phosphate; NAD; ammonium formate; ω-trans-aminase from Aspergillus terreus; alanine dehydrogenase from Bacillus sphaericus; alcohol dehydrogenase from Aromatoleum aromaticum; rac-Ala-OH; In aq. buffer; at 30 ℃; pH=8.5; Reagent/catalyst; stereoselective reaction; Catalytic behavior; Enzymatic reaction;
DOI:10.1002/cbic.202100123

Reference yield: 95.0%

: 40560-98-3
(1S,2R)-1-phenylpropane-1,2-diol

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

Guidance literature:: With pyridoxal 5'-phosphate; NAD; ammonium formate; 2,3-butanediol dehydrogenase from Bacillus subtilis BGSC₁ A₁; ω-trans-aminase from Aspergillus terreus; alanine dehydrogenase from Bacillus sphaericus; rac-Ala-OH; In aq. buffer; at 30 ℃; pH=8.5; Reagent/catalyst; stereoselective reaction; Catalytic behavior; Enzymatic reaction;
DOI:10.1002/cbic.202100123