Piperidin-4-yl-pyrimidin-2-yl-amine

Base Information

• Chemical Name: Piperidin-4-yl-pyrimidin-2-yl-amine
• CAS No.: 69385-85-9
• Molecular Formula: C9H14 N4
• Molecular Weight: 178.24
• Hs Code.: 2933990090
• Mol file: 69385-85-9.mol

Synonyms:2-(4-Piperidylamino)pyrimidine;N-Piperidin-4-ylpyrimidin-2-amine;

Chemical Property of Piperidin-4-yl-pyrimidin-2-yl-amine

Chemical Property:

• Vapor Pressure: 6.23E-05mmHg at 25°C
• Refractive Index: 1.588
• Boiling Point: 345.3oC at 760 mmHg
• PKA: 9.97±0.10(Predicted)
• Flash Point: 162.6oC
• PSA: 49.84000
• Density: 1.158g/cm3
• LogP: 1.04230
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

N-(Piperidin-4-yl)pyrimidin-2-amine >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperidin-4-yl-pyrimidin-2-yl-amine

There total 3 articles about Piperidin-4-yl-pyrimidin-2-yl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-benzyl-4-(2'-pyrimidylamino)piperidine (76167-42-5) → N-(4-piperidinyl)-2-pyrimidinamine (69385-85-9)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; at 60 ℃; for 2h; under 3102.97 Torr;

Reference yield:

4-amino-1-benzylpiperidine (50541-93-0) → N-(4-piperidinyl)-2-pyrimidinamine (69385-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 18 h / Heating / reflux

2: hydrogen / palladium dihydroxide / ethanol / 2 h / 60 °C / 3102.97 Torr

With hydrogen; palladium dihydroxide; In ethanol;

Reference yield:

→ N-(4-piperidinyl)-2-pyrimidinamine (69385-85-9)

Guidance literature:

aus d. N-Ethoxycarbonylverb.;

upstream raw materials:

1-benzyl-4-(2'-pyrimidylamino)piperidine

4-amino-1-benzylpiperidine

Refernces

• 1、 -. "Piperidine derivatives, compositions and use". . . Retrieved 2008/06/13.
• 2、 -. "N-aryl-N-(1-alkyl-4-piperidinyl)-arylacetamides". . . Retrieved 2008/06/13.