3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone

Base Information

• Chemical Name: 3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone
• CAS No.: 91712-99-1
• Molecular Formula: C₂₀H₂₅NO₅
• Molecular Weight: 359.422
• Mol file: 91712-99-1.mol

Synonyms:3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone

Chemical Property of 3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone

There total 10 articles about 3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-methylhydroxyamine hydrochloride (4229-44-1) + 3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one (91712-97-9) → 3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone (91712-99-1)

Guidance literature:

With sodium acetate; In ethanol; Heating;

DOI:10.1021/jo00194a026

Reference yield:

1,2-dimethoxybenzene (91-16-7) → 3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone (91712-99-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 1) n-BuLi, TMEDA / 1) hexane, ether, RT, 2 h, 2) RT, 18 h

2: 60 percent / 0.5 N H₂SO₄ / tetrahydrofuran / 20 h

3: p-toluenesulfonic acid monohydrate / benzene / 20 h / Heating

4: 1) BH₃, 2) 3N NaOH, 30 percent H₂O₂ / 1) THF, RT, overnight, 2a) 1 h, RT, 2b) 45 deg C, overnight

5: 88 percent / pyridinium chlorochromate / CH₂Cl₂

6: 1) NaH / 1) DME, 2) toluene, 36 h, reflux

7: 1) OsO₄, 2) NaIO₄ / 1) ether, water, 20 min, 2) 48 h

8: 90 percent / NaH, t-amyl alcohol / benzene / 0.5 h / Heating

9: 99 percent / sodium acetate / ethanol / Heating

With sodium hydroxide; sodium periodate; osmium(VIII) oxide; n-butyllithium; tert-Amyl alcohol; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; borane; dihydrogen peroxide; sodium acetate; sodium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; benzene;

DOI:10.1021/jo00194a026

Reference yield:

3-isopropoxycyclohex-2-en-1-one (58529-72-9) → 3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one N-methylnitrone (91712-99-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 1) n-BuLi, TMEDA / 1) hexane, ether, RT, 2 h, 2) RT, 18 h

2: 60 percent / 0.5 N H₂SO₄ / tetrahydrofuran / 20 h

3: p-toluenesulfonic acid monohydrate / benzene / 20 h / Heating

4: 1) BH₃, 2) 3N NaOH, 30 percent H₂O₂ / 1) THF, RT, overnight, 2a) 1 h, RT, 2b) 45 deg C, overnight

5: 88 percent / pyridinium chlorochromate / CH₂Cl₂

6: 1) NaH / 1) DME, 2) toluene, 36 h, reflux

7: 1) OsO₄, 2) NaIO₄ / 1) ether, water, 20 min, 2) 48 h

8: 90 percent / NaH, t-amyl alcohol / benzene / 0.5 h / Heating

9: 99 percent / sodium acetate / ethanol / Heating

With sodium hydroxide; sodium periodate; osmium(VIII) oxide; n-butyllithium; tert-Amyl alcohol; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; borane; dihydrogen peroxide; sodium acetate; sodium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; benzene;

DOI:10.1021/jo00194a026

upstream raw materials:

N-methylhydroxyamine hydrochloride

3a-(2,3-dimethoxyphenyl)-5,5-(ethylenedioxy)-3,3a,4,5,6,7-hexahydro-2H-inden-2-one

1,2-dimethoxybenzene

3-isopropoxycyclohex-2-en-1-one

Downstream raw materials:

4a-(2,3-dimethoxyphenyl)-6,6-(ethylenedioxy)-2-methyl-2,3,4,4a,5,6,7,8-octahydroisoquinoline

cis-4a-(2,3-dimethoxyphenyl)-2-methyl-6-oxo-3,4,4a,5,6,7,8,8a-octahydroisoquinolinium perchlorate

(3aS,7aS,7bS)-3a-(2,3-Dimethoxy-phenyl)-1a-methyl-5-oxo-decahydro-1a-azonia-cyclopropa[a]naphthalene; perchlorate

4a-(2,3-dimethoxyphenyl)-6,6-(ethylenedioxy)-2-methyl-3-oxo-2,3,4,4a,5,6,7,8-octahydroisoquinoline

Refernces