D-S-tert-Butylcysteine

Base Information

• Chemical Name: D-S-tert-Butylcysteine
• CAS No.: 2481-10-9
• Molecular Formula: C7H15NO2S
• Molecular Weight: 177.268
• Mol file: 2481-10-9.mol

Synonyms:Alanine,3-(tert-butylthio)- (7CI);Alanine, 3-(tert-butylthio)-, L- (8CI);S-tert-Butyl-L-cysteine;S-tert-Butylcysteine;

Chemical Property of D-S-tert-Butylcysteine

Chemical Property:

• Melting Point: 193 °C (decomp)
• Boiling Point: 293.5 °C at 760 mmHg
• PKA: 2.10±0.10(Predicted)
• Flash Point: 131.3 °C
• PSA: 88.62000
• Density: 1.13 g/cm³
• LogP: 1.63030

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-S-tert-Butylcysteine

There total 7 articles about D-S-tert-Butylcysteine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylpropan-2-thiol (75-66-1) → (R)-S-tert-butylcysteine (2481-10-9,300583-35-1) + (S)-2-N-(N-benzyl-L-prolyl)aminobenzophenone hydrochloride

Guidance literature:

2-methylpropan-2-thiol; (2-(N-[2-(N-benzyl-L-prolyl)aminophenyl](phenyl)methylene)aminoacrylato-N,N',N'',O)nickel(II); With potassium carbonate; In acetonitrile; at 40 - 45 ℃;

With hydrogenchloride; In methanol; at 45 - 50 ℃;

DOI:10.1007/BF02495097

Reference yield:

L-Cysteine (52-90-4) + tert-butyl alcohol (75-65-0) → (R)-S-tert-butylcysteine (2481-10-9,300583-35-1)

Guidance literature:

With trifluoroacetic acid; Ambient temperature;

Reference yield:

S-tert-Butyl-L-cysteine tert-Butyl Ester Hydrochloride (2481-11-0) → (R)-S-tert-butylcysteine (2481-10-9,300583-35-1)

Guidance literature:

With hydrogen bromide; acetic acid;

DOI:10.1021/ja00885a020

upstream raw materials:

S-t-butyl-L-cysteine t-butyl ester

S-tert-Butyl-L-cysteine tert-Butyl Ester Hydrochloride

L-Cysteine

tert-butyl alcohol

Downstream raw materials:

L-cystine

2-methylpropan-2-thiol

2-oxo-propionic acid

N-(Carbo-tert-butoxy)-S-tert-butyl-L-cysteine

Refernces

• 1、 Saghiyan,Geolchanyan,Djamgaryan,Vardapetyan,Tararov,Kuz'mina,Ikonnikov,Belokon',North. "Asymmetric synthesis of S-alkyl-substituted (R)-cysteines via a chiral NiII complex of the Schiff's base of dehydroalanine with (S)-2-N-(N-benzylprolyl)aminobenzophenone". . p. 1460 - 1463. Retrieved 2000.
• 2、 Uttamsing, Vinita,Keller,Anders. "Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N- acetyl-L-cysteines". . p. 800 - 809. Retrieved 2007/10/03.