1-Triphenylmethyl-4-methylimidazole

Base Information

• Chemical Name: 1-Triphenylmethyl-4-methylimidazole
• CAS No.: 82594-80-7
• Molecular Formula: C23H20N2
• Molecular Weight: 324.425
• Hs Code.: 2933290090
• Mol file: 82594-80-7.mol

Synonyms:1-Trityl-4-methylimidazole;4-Methyl-1-trityl-1H-imidazole;4-Methyl-1-tritylimidazole;5-Methyl-3-triphenylmethyl-3H-imidazole;CDD 3531;

Chemical Property of 1-Triphenylmethyl-4-methylimidazole

Chemical Property:

• Vapor Pressure: 1.96E-08mmHg at 25°C
• Refractive Index: 1.6
• Boiling Point: 466.5 °C at 760 mmHg
• Flash Point: 236 °C
• PSA: 17.82000
• Density: 1.05g/cm³
• LogP: 5.03170

Purity/Quality:

98%min ^*data from raw suppliers

4-Methyl-1-trityl-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Triphenylmethyl-4-methylimidazole

There total 2 articles about 1-Triphenylmethyl-4-methylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

4-methyl-1H-imidazole (822-36-6) + trityl chloride (76-83-5) → 4-methyl-1-trityl-1H-imidazole (82594-80-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 3.5h;

Reference yield: 89.0%

→ 4-methyl-1-trityl-1H-imidazole (82594-80-7)

Guidance literature:

Reference yield: 85.0%

4-methyl-1-trityl-1H-imidazole (82594-80-7) + α-bromoacetophenone (70-11-1) → 4-methyl-3-phenacyl-1-triphenylmethylimidazolium bromide (115383-28-3)

Guidance literature:

In diethyl ether; dichloromethane; for 48h; Ambient temperature;

DOI:10.1055/s-1987-28187

upstream raw materials:

4-methyl-1H-imidazole

trityl chloride

Downstream raw materials:

4-methyl-2-nitroimidazole

4-methyl-3-phenacyl-1-triphenylmethylimidazolium bromide

1-(4-Methyl-1-trityl-1H-imidazol-2-yl)-2-trityloxy-ethanol

4-methyl-1-(triphenylmethyl)-1H-imidazole-2-carbaldehyde

Refernces

• 1、 Lee, Jeewoo,Tran, Phuong-Thao,Hoang, Van-Hai,Thorat, Shivaji A.,Kim, Sung Eun,Ann, Jihyae,Chang, Yu Jin,Nam, Dong Woo,Song, Hyundong,Mook-Jung, Inhee,Lee, Jiyoun. "Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template". . p. 3821 - 3830. Retrieved 2013/07/19.
• 2、 Roumen, Luc,Peeters, Joris W.,Emmen, Judith M. A.,Beugels, Ilona P. E.,Custers, Erica M. G.,De Gooyer, Marcel,Plate, Ralf,Pieterse, Koen,Hilbers, Peter A. J.,Smits, Jos F. M.,Vekemans, Jef A. J.,Leysen, Dirk,Ottenheijm, Harry C. J.,Janssen, Henk M.,Rob Hermans. "Synthesis, Biological Evaluation, and Molecular Modeling of 1 -Benzyl-1H-imidazoles as Selective Inhibitors of Aldosterone Synthase (CYP11B2)". experimental part. p. 1712 - 1725. Retrieved 2010/07/17.