2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride

Base Information

• Chemical Name: 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride
• CAS No.: 1185-53-1
• Molecular Formula: C4H12ClNO3
• Molecular Weight: 157.597
• Hs Code.: 29221980
• Mol file: 1185-53-1.mol

Synonyms:Tris(Hydroxymethyl)aminomethane hydrochloride [TRIS·HCL];Tris HCl;Tris-HCL;1,3-Propanediol,2-amino-2-(hydroxymethyl)-, hydrochloride (8CI,9CI);2-Amino-2-(hydroxymethyl)-1,3-propanediolhydrochloride;T 6666;Tri(hydroxymethyl)aminomethane hydrochloride;Trischloride;Tris(hydroxymethyl)aminomethane hydrochloride;Trizma hydrochloride;

Chemical Property of 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0Pa at 20℃
• Melting Point: 150-152 ºC
• Boiling Point: 357 ºC at 760 mmHg
• PKA: 8.1(at 25℃)
• Flash Point: 169.7 ºC
• PSA: 86.71000
• Density: 1.05g/mLat 20°C
• LogP: -0.83690
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: H2O: 4 M at 20 °C, clear, colorless
• Water Solubility.: SOLUBLE
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 157.0505709
• Heavy Atom Count: 9
• Complexity: 54

Purity/Quality:

98%99% ^*data from raw suppliers

Tris Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C(CO)(CO)[NH3+])O.[Cl-]
• Description: 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride (Tris-HCl), is composed of 2-amino-2-(hydroxymethyl)propane-1,3-diol and hydrochloric acid. It's chemical structure consists of a tris(hydroxymethyl)aminomethane molecule (commonly known as Tris) combined with a chloride ion.
• Uses and Mechanism of Action: 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride (Tris-HCl) is primarily used as a buffering agent in various fields, including laboratory chemicals, pH regulators, water treatment products, and chemicals for health services and scientific research. Tris-HCl is utilized to maintain a stable pH environment, particularly in applications where an acidic pH is required. Tris-HCl can influence the corrosion behavior of certain metals, such as magnesium and zinc alloys, in various environments by affecting pH levels and the formation of corrosion products.
• Production Methods: 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride (Tris-HCl) is typically synthesized by combining tris(hydroxymethyl)aminomethane with hydrochloric acid.
• References: [1] Measurement of pHT values of Tris buffers in artificial seawater at varying mole ratios of Tris:Tris·HCl; DOI 10.1016/j.marchem.2014.03.003; [2] New insights into the effect of Tris-HCl and Tris on corrosion of magnesium alloy in presence of bicarbonate, sulfate, hydrogen phosphate and dihydrogen phosphate ions; DOI 10.1016/j.jmst.2017.01.005; [3] Local pH and oxygen concentration at the interface of Zn alloys in Tris-HCl or HEPES buffered Hanks’ balanced salt solution; DOI 10.1016/j.corsci.2021.110061

Technology Process of 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride

There total 3 articles about 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

cis-2,8-diphenyl-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane → tris hydrochloride (1185-53-1)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; Heating;

DOI:10.1016/S0040-4020(02)01287-5

Reference yield:

2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → tris hydrochloride (1185-53-1)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 3h;

Reference yield:

→ tris hydrochloride (1185-53-1)

Guidance literature:

upstream raw materials:

2-amino-2-hydroxymethyl-1,3-propanediol

Downstream raw materials:

5-amino-5-hydroxymethyl-2-phenyl-1,3-dioxane

L-enterobactin

2,3-dihydroxybenzoyl-L-serine

N,N',N''-tris(2,3-dihydroxybenzoyl)-O-L-seryl-O-L-seryl L-serine

Refernces

• 1、 -. "PRIMER FOR AMPLIFICATION OF RRNA OR BACTERIUM BELONGING TO THE GENUS LEGIONELLA, DETECTION METHOD, AND DETECTION KIT". . . Retrieved 2010/12/29.
• 2、 Sélambarom, Jimmy,Monge, Sophie,Carré, Francis,Roque, Jean Pierre,Pavia, André A. "Stereoelectronic control of oxazolidine ring-opening: Structural and chemical evidences". . p. 9559 - 9566. Retrieved 2007/10/03.