2-Methylthiazole-4-carbohydrazide

Base Information

• Chemical Name: 2-Methylthiazole-4-carbohydrazide
• CAS No.: 101767-28-6
• Molecular Formula: C5H7N3OS
• Molecular Weight: 157.196
• Hs Code.: 2934100090
• European Community (EC) Number: 671-517-2
• DSSTox Substance ID: DTXSID00372517
• Wikidata: Q72491206
• Mol file: 101767-28-6.mol

Synonyms:2-Methylthiazole-4-carbohydrazide;101767-28-6;2-Methyl-thiazole-4-carboxylic acid hydrazide;2-methyl-1,3-thiazole-4-carbohydrazide;2-methylthiazole-4-carboxylic acid hydrazide;4-Thiazolecarboxylic acid, 2-methyl-, hydrazide;MFCD00662677;Maybridge1_008436;Oprea1_810916;SCHEMBL1130953;HMS565H10;2-methyl-4-thiazolecarbohydrazide;DTXSID00372517;AKOS005203453;CS-W002656;SB30150;AC-29347;CS-11430;SY020619;(E)-3,3,4,5-TETRAMETHOXYSTILBENE;4-Thiazolecarboxylicacid,2-methyl-,hydrazide;AM20120536;FT-0691813;J-510111;F9995-1803

Chemical Property of 2-Methylthiazole-4-carbohydrazide

Chemical Property:

• Melting Point: 126-129 °C
• Refractive Index: 1.607
• PKA: 11.12±0.10(Predicted)
• PSA: 96.25000
• Density: 1.355 g/cm³
• LogP: 1.14620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 157.03098303
• Heavy Atom Count: 10
• Complexity: 141

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-4-thiazolecarboxylic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CS1)C(=O)NN

Technology Process of 2-Methylthiazole-4-carbohydrazide

There total 1 articles about 2-Methylthiazole-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

ethyl 2-methylthiazole-4-carboxylate (6436-59-5) → 2-methylthiazole-4-carbohydrazide (101767-28-6)

Guidance literature:

With hydrazine hydrate; In methanol; at 60 ℃; for 1h;

DOI:10.1071/CH9851257

Reference yield: 84.0%

(R)-1-(2,4-dimethoxybenzyl)-5-ethoxy-6-methyl-1,2,3,6-tetrahydropyrazine (1429560-52-0) + 2-methylthiazole-4-carbohydrazide (101767-28-6) → (R)-4-(7-(2,4-dimethoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-methylthiazole (1429607-62-4)

Guidance literature:

In methanol; at 60 - 70 ℃; for 8h; Inert atmosphere;

DOI:10.1021/jm5017413

Reference yield: 59.0%

(S)-1-(2,4-dimethoxybenzyl)-5-ethoxy-6-methyl-1,2,3,6-tetrahydropyrazine (1429560-54-2) + 2-methylthiazole-4-carbohydrazide (101767-28-6) → (S)-4-(7-(2,4-dimethoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-methylthiazole (1429558-36-0)

Guidance literature:

In methanol; at 60 - 70 ℃; for 8h; Inert atmosphere;

DOI:10.1021/jm5017413

upstream raw materials:

ethyl 2-methylthiazole-4-carboxylate

Downstream raw materials:

(R)-(8-methyl-3-(2-methylthiazol-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone

(R)-4-(7-(2,4-dimethoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-methylthiazole

(S)-4-(7-(2,4-dimethoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-2-methylthiazole

(S)-(8-methyl-3-(2-methylthiazol-4-yl)-5,6-dihydro-[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone

Refernces

• 1、 Hoveyda, Hamid R.,Fraser, Graeme L.,Roy, Marie-Odile,Dutheuil, Guillaume,Batt, Frédéric,El Bousmaqui, Mohamed,Korac, Julien,Lenoir, Fran?ois,Lapin, Alexey,No?l, Sophie,Blanc, Sébastien. "Discovery and Optimization of Novel Antagonists to the Human Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part I)". . p. 3060 - 3082. Retrieved 2015/04/27.
• 2、 Cowden,Sullivan,Brown. "Unfused heterobicycles as amplifiers of phleomycin. VIII . Some bithiazoles: Thienyl-, furanyl- and thiazolyl-thiadiazoles and related oxadiazoles". . p. 1257 - 1261. Retrieved 2007/10/02.