Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate

Base Information

• Chemical Name: Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate
• CAS No.: 91374-24-2
• Molecular Formula: C19H28 N2 O5
• Molecular Weight: 364.442
• Mol file: 91374-24-2.mol

Synonyms:2-[2-(Dipropylamino)ethyl]-6-nitro-alpha-oxobenzenepropanoic acid ethyl ester

Chemical Property of Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate

Chemical Property:

• Vapor Pressure: 1.58E-09mmHg at 25°C
• Boiling Point: 484.2°C at 760 mmHg
• PKA: 9.24±0.50(Predicted)
• Flash Point: 246.6°C
• PSA: 92.43000
• Density: 1.127
• LogP: 3.45720

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-[2-(Dipropylamino)ethyl]-6-nitrophenylPyruvate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2-[2-(Dipropylamino)ethyl]-6-nitrophenyl Pyruvate is an impurity of Ropinirol (R641000), a antiparkinsonian agent. A selective dopamine D2-receptor agonist.

Technology Process of Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate

There total 3 articles about Ethyl 3-[2-[2-(dipropylamino)ethyl]-6-nitrophenyl]-2-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride (920986-68-1) + oxalic acid diethyl ester (95-92-1) → ethyl 6-[2-(di-n-propylamino)ethyl]-2-nitrophenyl pyruvate (91374-24-2)

Guidance literature:

oxalic acid diethyl ester; With ethanol; sodium; In tetrahydrofuran; at 15 - 30 ℃; Inert atmosphere;

N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride; In tetrahydrofuran; at 25 - 30 ℃;

Reference yield:

1-(2-dipropylaminoethyl)-2-methyl-3-nitrobenzene (91374-23-1) → ethyl 6-[2-(di-n-propylamino)ethyl]-2-nitrophenyl pyruvate (91374-24-2)

Guidance literature:

oxalic acid diethyl ester; With sodium ethanolate; In tetrahydrofuran; ethanol; for 0.25h;

1-(2-dipropylaminoethyl)-2-methyl-3-nitrobenzene; In tetrahydrofuran; ethanol; at 20 - 30 ℃; for 20 - 24h;

With hydrogenchloride; In water; ethyl acetate; pH=7.5 - 8.0; Product distribution / selectivity;

Reference yield:

→ ethyl 6-[2-(di-n-propylamino)ethyl]-2-nitrophenyl pyruvate (91374-24-2)

Guidance literature:

upstream raw materials:

1-(2-dipropylaminoethyl)-2-methyl-3-nitrobenzene

N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride

oxalic acid diethyl ester

Downstream raw materials:

<2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE". Page/Page column 25. . Retrieved 2008/06/13.
• 2、 -. "4-Aminoalkyl-2(3H)-indolones". . . Retrieved 2008/06/13.