4',4,4''-TRIMETHYL-2,2':6',2''-TERPYRIDINE

Base Information

• Chemical Name: 4',4,4''-TRIMETHYL-2,2':6',2''-TERPYRIDINE
• CAS No.: 33354-75-5
• Molecular Formula: C18H17N3
• Molecular Weight: 275.353
• Hs Code.: 2933399090
• Mol file: 33354-75-5.mol

Synonyms:2,2':6',2''-Ter-4-picoline(8CI);4,4',4''-Trimethyl-2,2':6',2''-terpyridine;2,2':6',2''-Terpyridine,4,4',4''-trimethyl- (9CI);2,2':6',2''-Ter-4-picoline;

Chemical Property of 4',4,4''-TRIMETHYL-2,2':6',2''-TERPYRIDINE

Chemical Property:

• Boiling Point: 422.5 °C at 760 mmHg
• PKA: 5.51±0.42(Predicted)
• Flash Point: 183.9 °C
• PSA: 38.67000
• Density: 1.108 g/cm³
• LogP: 4.13080

Purity/Quality:

99.0% ^*data from raw suppliers

4,4',4''-Trimethyl-2,2':6',2''-terpyridine, 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4',4,4''-TRIMETHYL-2,2':6',2''-TERPYRIDINE

There total 3 articles about 4',4,4''-TRIMETHYL-2,2':6',2''-TERPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2,6-Dibromo-4-methylpyridine (73112-16-0) + 4-methyl-2-(tri-n-butylstannyl)pyridine (301652-23-3) → 4,4',4-trimethyl-2,2':6',2-terpyridine (33354-75-5)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 16h;

DOI:10.1055/s-2000-8216

Reference yield:

4-methyl-2,6-dihydroxypyridine (4664-16-8) → 4,4',4-trimethyl-2,2':6',2-terpyridine (33354-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / PBr₃ / 6 h / 175 °C

2: 55 percent / (Ph₃P)4Pd / toluene / 16 h / 110 °C

With phosphorus tribromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; 1: Substitution / 2: Substitution;

DOI:10.1055/s-2000-8216

Reference yield:

→ 4,4',4-trimethyl-2,2':6',2-terpyridine (33354-75-5)

Guidance literature:

upstream raw materials:

2,6-Dibromo-4-methylpyridine

4-methyl-2-(tri-n-butylstannyl)pyridine

4-methyl-2,6-dihydroxypyridine

Downstream raw materials:

trimethyl 2,2:6′,2''-terpyridine-4,4',4''-tricarboxylate

4,4',4-tricarboxy-2,2':6',2-terpyridine

Refernces