METHACYCLINE HYDROCHLORIDE

Base Information

• Chemical Name: METHACYCLINE HYDROCHLORIDE
• CAS No.: 3963-45-9
• Molecular Formula: C₁₉H₂₄O₂
• Molecular Weight: 284.398
• Mol file: 3963-45-9.mol

Synonyms:Androsta-4,6-dien-3,17-dion; androsta-4,6-diene-3,17-dione;

Chemical Property of METHACYCLINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 5.4E-28mmHg at 25°C
• Boiling Point: 813.8 °C at 760 mmHg
• Flash Point: 445.9 °C
• PSA: 181.62000
• LogP: 1.06440

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Safety Statements: S22:; S24/25:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHACYCLINE HYDROCHLORIDE

There total 6 articles about METHACYCLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

C19H26O2 → (8R,9S,10R,13S)-10,13-dimethyl-9,10,11,12,13,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,8H)-dione (633-34-1,3963-45-9,4080-56-2,4105-45-7,61217-25-2)

Guidance literature:

With C₁₂H₁₂F₆O₄Pt; chlorobenzene; p-benzoquinone; barium(II) oxide; at 80 ℃; for 12h; Inert atmosphere; Glovebox;

DOI:10.1002/anie.202013628

Reference yield:

→ androsta-4,6-diene-3,17-dione (633-34-1,3963-45-9,4080-56-2,4105-45-7,61217-25-2)

Guidance literature:

Azid (2a), KOH/A. sowie Oxid.;

DOI:10.1016/S0040-4020(01)92971-0

Reference yield:

→ 4,6-Androstadien-3,17-dion (633-34-1,3963-45-9,4080-56-2,4105-45-7,61217-25-2)

Guidance literature:

/BRN= 929/, MnO2;

Refernces

• 1、 Chen, Ming,Dong, Guangbin. "Platinum-Catalyzed α,β-Desaturation of Cyclic Ketones through Direct Metal–Enolate Formation". supporting information. p. 7956 - 7961. Retrieved 2021/03/01.
• 2、 Grunwell,Benson,Johnston,Petrow. "Antiprogestational agents. The synthesis of 7 alkyl steroidal ketones with anti implantational and antidecidual activity". . p. 759 - 771. Retrieved 2007/10/15.