FMOC-D-PHENYLALANINOL

Base Information

• Chemical Name: FMOC-D-PHENYLALANINOL
• CAS No.: 130406-30-3
• Molecular Formula: C24H23NO3
• Molecular Weight: 373.452
• Hs Code.: 2924299090
• Mol file: 130406-30-3.mol

Synonyms:Fmoc-d-Phenylalaninol;

Chemical Property of FMOC-D-PHENYLALANINOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 147 °C(Solv: ethyl acetate (141-78-6))
• Refractive Index: 1.626
• Boiling Point: 606.125 °C at 760 mmHg
• PKA: 11.44±0.46(Predicted)
• Flash Point: 320.373 °C
• PSA: 58.56000
• Density: 1.219 g/cm³
• LogP: 4.51960
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-D-Phenylalaninol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-D-PHENYLALANINOL

There total 3 articles about FMOC-D-PHENYLALANINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(-)-(R)-(N-9-fluorenylmethoxycarbonyl)phenylalaninal (146803-47-6) → 9H-fluoren-9-ylmethyl (R)-<1-(hydroxymethyl)-2-phenylethyl>carbamate (130406-30-3)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/jo00060a056

Reference yield: 90.0%

(R)-2-amino-3-phenylpropanol (5267-64-1) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 9H-fluoren-9-ylmethyl (R)-<1-(hydroxymethyl)-2-phenylethyl>carbamate (130406-30-3)

Guidance literature:

In 1,4-dioxane; water; for 18h; Ambient temperature;

DOI:10.1021/jm00105a062

Reference yield: 32.0%

C26H25NO4 (1235475-85-0) → 9H-fluoren-9-ylmethyl (R)-<1-(hydroxymethyl)-2-phenylethyl>carbamate (130406-30-3)

Guidance literature:

With porcine pancreatic lipase; In hexane; toluene; at 37 ℃; for 3h; pH=7; optical yield given as %ee; aq. phosphate buffer; Enzymatic reaction;

DOI:10.2174/157017810790796327

upstream raw materials:

(R)-2-amino-3-phenylpropanol

(fluorenylmethoxy)carbonyl chloride

(-)-(R)-(N-9-fluorenylmethoxycarbonyl)phenylalaninal

C₂₆H₂₅NO₄

Downstream raw materials:

(R)-2-amino-3-phenylpropanol

[(S)-1-((R)-1-Aminomethyl-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester

[(R)-1-((R)-1-Aminomethyl-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester

(R)-α-(azidomethyl)-2-phenylethanamine

Refernces

• 1、 Chen, Jack J.,Aduda, Vince. "DMSO-aided o-iodoxybenzoic acid (IBX) oxidation of Fmoc-protected amino alcohols". . p. 3493 - 3499. Retrieved 2008/03/13.
• 2、 Ho, Pak T.,Ngu, Kheh-yong. "An Effective Synthesis of N-(9-Fluorenylmethyloxycarbonyl) α-Amino Aldehydes from S-Benzyl Thioesters". . p. 2313 - 2316. Retrieved 2007/10/02.