2-Amino-4-(trifluoromethyl)pyrimidine

Base Information

• Chemical Name: 2-Amino-4-(trifluoromethyl)pyrimidine
• CAS No.: 16075-42-6
• Molecular Formula: C5H4F3N3
• Molecular Weight: 163.102
• Hs Code.: 29335990
• Mol file: 16075-42-6.mol

Synonyms:4-(Trifluoromethyl)-2-pyrimidinamine;

Chemical Property of 2-Amino-4-(trifluoromethyl)pyrimidine

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Melting Point: 175-177 °C
• Refractive Index: 1.363
• Boiling Point: 260.7 °C at 760 mmHg
• PKA: 1.90±0.10(Predicted)
• Flash Point: 111.5 °C
• PSA: 51.80000
• Density: 1.46 g/cm³
• LogP: 1.65880
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-(trifluoromethyl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,N,T
• Statements: 36/37/38-50-43-36-25
• Safety Statements: 26-36/37/39-61-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-4-(trifluoromethyl)pyrimidine

There total 1 articles about 2-Amino-4-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-4-(trifluoromethyl)-2-pyrimidylamine (935534-47-7) + bis(pinacol)diborane (73183-34-3) → 5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))-4-(trifluoromethyl)pyrimidine-2-ylamine (944401-58-5) + 2-amino-4-trifluoromethylpyrimidine (16075-42-6)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 115 ℃; for 6h;

Reference yield: 88.0%

cyclohexane (110-82-7,25012-93-5) + 2-amino-4-trifluoromethylpyrimidine (16075-42-6) → 4-cyclohexyl-6-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:

With hydrogenchloride; Selectfluor; In water; acetone; at 20 ℃; for 16h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.9b01635

Reference yield: 42.0%

1-(4-methoxyphenyl)-1,3-pentanedione (54103-36-5) + 2-amino-4-trifluoromethylpyrimidine (16075-42-6) → (2-ethyl-7-(trifluoromethyl)imidazo[1,2-a]pyrimidin-3-yl) (4-methoxyphenyl)methanone

Guidance literature:

1-(4-methoxyphenyl)-1,3-pentanedione; 2-amino-4-trifluoromethylpyrimidine; With [bis(acetoxy)iodo]benzene; In tetrahydrofuran; at 20 ℃; for 2h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 20 ℃; for 16h;

upstream raw materials:

5-bromo-4-(trifluoromethyl)-2-pyrimidylamine

bis(pinacol)diborane

Downstream raw materials:

3-bromo-7-(trifluoromethyl)imidazo[1,2-a]-pyrimidine

C₅H₅BF₃N₃O₂

(S)-3-(2'-amino-2-(morpholin-4-yl)-4'-trifluoromethyl-[4,5']bipyrimidinyl-6-yl)-4-(((tert-butyldiphenylsilanyl)oxy)methyl)-[1,3]oxazinan-2-one

Refernces

• 1、 -. "METHOD OF INHIBITING HAMARTOMA TUMOR CELLS". Page/Page column 21. . Retrieved 2012/08/28.
• 2、 -. "PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE". Page/Page column 63-64. . Retrieved 2008/12/08.