2,6-Diamino-3,5-difluoropyridine

Base Information

• Chemical Name: 2,6-Diamino-3,5-difluoropyridine
• CAS No.: 247069-27-8
• Molecular Formula: C5H5F2N3
• Molecular Weight: 145.112
• Hs Code.: 29333990
• European Community (EC) Number: 623-869-3
• DSSTox Substance ID: DTXSID20436387
• Nikkaji Number: J2.551.552H
• Wikidata: Q72464221
• Mol file: 247069-27-8.mol

Synonyms:247069-27-8;2,6-Diamino-3,5-difluoropyridine;3,5-difluoropyridine-2,6-diamine;2,6-Pyridinediamine, 3,5-difluoro-;MFCD03412208;3,5-Difluoro-2,6-pyridinediamine;SCHEMBL1565794;DTXSID20436387;3,5-Difluoro-2,6-Diaminepyridine;BCP12879;5-Bromo-3-fluoro-2-methoxy-pyridine;AKOS005063500;AC-6902;AM85679;SB52431;DS-13619;SY064711;2,6-Diamino-3,5-difluoropyridine, 97%;A5063;CS-0004259;FT-0630263;2 pound not6-Diamino-3 pound not5-difluoropyridine;J-507392;2,6-DIAMINO-3,5-DIFLUOROPYRIDINE

Chemical Property of 2,6-Diamino-3,5-difluoropyridine

Chemical Property:

• Vapor Pressure: 0.056mmHg at 25°C
• Melting Point: 160 °C
• Refractive Index: 1.602
• Boiling Point: 233.265 °C at 760 mmHg
• PKA: 1.93±0.10(Predicted)
• Flash Point: 94.876 °C
• PSA: 64.93000
• Density: 1.517 g/cm³
• LogP: 1.68660
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 145.04515350
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

98%, ^*data from raw suppliers

3,5-Difluoropyridine-2,6-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T
• Hazard Codes: Xi,T
• Statements: 21/22-36/37-36
• Safety Statements: 24-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=NC(=C1F)N)N)F
• Physical properties: 3,5-Difluoropyridine-2,6-diamine is soluble in water (slightly).
• Uses: 3,5-Difluoropyridine-2,6-diamine is a reagent used for the synthesis of 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone which is possessed antimycobacterial and antibacterial activity.

Technology Process of 2,6-Diamino-3,5-difluoropyridine

There total 6 articles about 2,6-Diamino-3,5-difluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C17H13F2N3O4S2 → 2,6-diamino-3,5-difluoropyridine (247069-27-8)

Guidance literature:

With sulfuric acid; at 20 ℃; for 1h;

Reference yield: 95.0%

C13H21F2N3O4S2 → 2,6-diamino-3,5-difluoropyridine (247069-27-8)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 2h;

Reference yield: 91.0%

2,3,5,6-tetrafluoropyridine (2875-18-5) → 2,6-diamino-3,5-difluoropyridine (247069-27-8)

Guidance literature:

With ammonium hydroxide; In ethanol; at 30 ℃; for 3h; Time; Green chemistry;

upstream raw materials:

N₂,N₆-dibenzyl-2,6-diamino-3,5-difluoropyridine

2,3,5,6-tetrafluoropyridine

2,3,4,5,6-pentachloropyridine

Downstream raw materials:

1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

(E)-1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

(Z)-1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Refernces

• 1、 -. "Preparation method of 3,5-difluoro-2,6-diaminopyridine". Paragraph 0017-0019. . Retrieved 2019/02/04.
• 2、 Vaganova,Kusov,Rodionov,Shundrina,Malykhin. "Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia". . p. 2239 - 2246. Retrieved 2008/09/20.