4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE

Base Information

• Chemical Name: 4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE
• CAS No.: 41192-84-1
• Molecular Formula: C11H8F3NO2
• Molecular Weight: 243.18
• Hs Code.: 2933499090
• Mol file: 41192-84-1.mol

Synonyms:4-Hydroxy-8-methoxy-2-(trifluoromethyl)quinoline;8-Methoxy-2-(trifluoromethyl)-4-hydroxyquinoline;

Chemical Property of 4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE

Chemical Property:

• Vapor Pressure: 0.00491mmHg at 25°C
• Refractive Index: 1.509
• Boiling Point: 276.1 °C at 760 mmHg
• Flash Point: 120.8 °C
• PSA: 42.35000
• Density: 1.372 g/cm³
• LogP: 2.96780
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Hydroxy-8-methoxy-2-(trifluoromethyl)quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE

There total 4 articles about 4-HYDROXY-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-methoxy-phenylamine (90-04-0) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 8-methoxy-2-trifluoromethyl-1H-quinolin-4-one (41192-84-1)

Guidance literature:

With polyphosphoric acid; at 20 - 120 ℃; for 2h; Inert atmosphere;

Reference yield:

ethyl 4,4,4-trifluorobutanoate (371-26-6) + 2-methoxy-phenylamine (90-04-0) → 8-Methoxy-2-trifluoromethylquinolin-4-one (474125-09-2,41192-84-1)

Guidance literature:

In diphenylether; at 100 - 250 ℃; for 2h;

Reference yield:

2-methoxy-phenylamine (90-04-0) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 8-Methoxy-2-trifluoromethylquinolin-4-one (474125-09-2,41192-84-1)

Guidance literature:

With PPA;

DOI:10.1016/S0960-894X(02)00224-X

upstream raw materials:

2-methoxy-phenylamine

ethyl 4,4,4-trifluoroacetoacetate

ethyl 4,4,4-trifluorobutanoate

Downstream raw materials:

4-chloro-8-methoxy-2-trifluoromethyl-quinoline

8-Methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid

3-benzyl-7-methoxy-5-trifluoromethyl-3,4-dihydro-2H-[1,3]oxazino[5,6-c]quinoline

Refernces

• 1、 Meshram, H. M.,Chennakesava Reddy, B.,Aravind Kumar, D.,Kalyan, M.,Ramesh, P.,Kavitha, P.,Venkateswara Rao, J.. "Synthesis and cytotoxicity of new quinoline derivatives". . p. 1411 - 1416,6. Retrieved 2020/08/31.
• 2、 -. "PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT". Page/Page column 59. . Retrieved 2010/04/25.