2-FLUORO-6-METHOXYANILINE

Base Information

• Chemical Name: 2-FLUORO-6-METHOXYANILINE
• CAS No.: 446-61-7
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.145
• Hs Code.: 2922299090
• Mol file: 446-61-7.mol

Synonyms:o-Anisidine,6-fluoro- (8CI);

Chemical Property of 2-FLUORO-6-METHOXYANILINE

Chemical Property:

• Boiling Point: 189.169 °C at 760 mmHg
• PKA: 3.15±0.10(Predicted)
• Flash Point: 68.208 °C
• PSA: 35.25000
• Density: 1.177 g/cm³
• LogP: 1.99770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

2-Fluoro-6-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of 2-FLUORO-6-METHOXYANILINE

There total 6 articles about 2-FLUORO-6-METHOXYANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-fluoro-3-methoxy-2-nitrobenzene (641-49-6) → 2-fluoro-6-methoxyphenylamine (446-61-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; under 2585.81 Torr;

Reference yield: 67.0%

5-[(2-fluoro-6-methoxyphenyl)imino]-5H-5γ4-dibenzo[b,d]thiophene-5-oxide → 2-fluoro-6-methoxyphenylamine (446-61-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In toluene; at 100 ℃; Sealed tube;

DOI:10.1002/anie.201705025

Reference yield:

3-methoxy-2-nitrobenzoic acid (4920-80-3) → 2-fluoro-6-methoxyphenylamine (446-61-7)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂

2: 1.) NaN₃, 2.) H₂O, 4.) NaOH, 5.) HCl

3: 1.) NaNO₂, HCl, 2.) NaSbF₆, 3.) SiO₂

4: H₂ / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr

With hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sodium hexafluoroantimonate; water; hydrogen; silica gel; sodium nitrite; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jm00063a014

upstream raw materials:

1-fluoro-3-methoxy-2-nitrobenzene

3-methoxy-2-nitrobenzoic acid

3-methoxy-2-nitroaniline

2-nitro-3-methoxybenzoyl chloride

Downstream raw materials:

2-chloro-1-fluoro-3-methoxybenzene

2‐bromo‐1‐fluoro‐3‐methoxybenzene

1-fluoro-2-iodo-3-methoxybenzene

1-(2-Fluoro-6-methoxy-phenyl)-3-pentyl-urea

Refernces

• 1、 -. "1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS". Page/Page column 248. . Retrieved 2018/04/27.
• 2、 Kimura,Watanabe,Matsui,Hayashi,Tanaka,Ohtsuka,Saeki,Kogushi,Kabayashi,Akasaka,Yamagishi,Saitou,Yamatsu. "Structure-activity relationship of a series of phenylureas linked to 4- phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O- acyltransferase with antiatherosclerotic activity. 2". . p. 1641 - 1653. Retrieved 2007/10/02.