1,2-Bis(4-bromophenoxy)ethane

Base Information

• Chemical Name: 1,2-Bis(4-bromophenoxy)ethane
• CAS No.: 36506-46-4
• Molecular Formula: C14H12Br2O2
• Molecular Weight: 372.056
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID90555413
• Nikkaji Number: J1.572.161H
• Wikidata: Q82436746
• Mol file: 36506-46-4.mol

Synonyms:1,2-BIS(4-BROMOPHENOXY)ETHANE;36506-46-4;1-bromo-4-[2-(4-bromophenoxy)ethoxy]benzene;1,2-bis-(4-Bromophenoxy)ethane;3-chloro-propionylchloride;SCHEMBL6557649;DTXSID90555413;AKOS006037105;F75062;1,1'-[Ethane-1,2-diylbis(oxy)]bis(4-bromobenzene)

Chemical Property of 1,2-Bis(4-bromophenoxy)ethane

Chemical Property:

• Vapor Pressure: 1.74E-07mmHg at 25°C
• Melting Point: 134-135 °C
• Refractive Index: 1.602
• Boiling Point: 438.7 °C at 760 mmHg
• Flash Point: 182.1 °C
• PSA: 18.46000
• Density: 1.612 g/cm³
• LogP: 4.66940
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 371.91836
• Heavy Atom Count: 18
• Complexity: 198

Purity/Quality:

98%Min ^*data from raw suppliers

1,2-Bis(4-bromophenoxy)ethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1OCCOC2=CC=C(C=C2)Br)Br
• Uses: 1,2-Bis(4-bromophenoxy)ethane is a useful synthesis intermediate.

Technology Process of 1,2-Bis(4-bromophenoxy)ethane

There total 6 articles about 1,2-Bis(4-bromophenoxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,2-diphenoxyethane (104-66-5) → 4,4'-(ethylenedioxy)dibromobenzene (36506-46-4)

Guidance literature:

With bromine; In acetic acid; for 1h; Ambient temperature;

DOI:10.1016/S0008-6215(00)90884-X

Reference yield: 57.0%

4-bromo-phenol (106-41-2) + ethylene dibromide (106-93-4) → 4,4'-(ethylenedioxy)dibromobenzene (36506-46-4)

Guidance literature:

4-bromo-phenol; With sodium hydroxide; In water; at 60 - 70 ℃; for 0.5h;

ethylene dibromide; In water; at 100 ℃; for 6h;

DOI:10.1021/ja200840p

Reference yield:

potassium phenolate (100-67-4) → 4,4'-(ethylenedioxy)dibromobenzene (36506-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.2-dichloro-ethane; water

2: glacial acetic acid; bromine

With water; bromine; acetic acid; 1,2-dichloro-ethane;

DOI:10.1021/ja01306a056

upstream raw materials:

1,2-diphenoxyethane

4-bromo-phenol

ethylene dibromide

bromine

Downstream raw materials:

4-(4-{2-[4-(3-Hydroxy-3-methyl-but-1-ynyl)-phenoxy]-ethoxy}-phenyl)-2-methyl-but-3-yn-2-ol

(Z)-(4,4′-(ethene-1,2-diylbis(oxy))bis(1,4-phenylene))dimethanol

(Z)-4,4'-(ethene-1,2-diylbis(oxy))dibenzaldehyde

[(η1-Ph2PS-η1)Fe2(CO)6]2(4-μ-SC6H4OCH2CH2OC6H4S-μ-4')

Refernces

• 1、 Zhang, Rui,Peterson, Joshua P.,Fischer, Logan J.,Ellern, Arkady,Winter, Arthur H.. "Effect of Structure on the Spin-Spin Interactions of Tethered Dicyanomethyl Diradicals". supporting information. p. 14308 - 14313. Retrieved 2018/10/24.
• 2、 Zamadar, Matibur,Ghosh, Goutam,Mahendran, Adaickapillai,Minnis, Mihaela,Kruft, Bonnie I.,Ghogare, Ashwini,Aebisher, David,Greer, Alexander. "Photosensitizer drug delivery via an optical fiber". supporting information; experimental part. p. 7882 - 7891. Retrieved 2011/06/27.