1-Propylpiperazine

Base Information

• Chemical Name: 1-Propylpiperazine
• CAS No.: 21867-64-1
• Molecular Formula: C7H16N2
• Molecular Weight: 128.217
• Hs Code.: 2933599090
• Mol file: 21867-64-1.mol

Synonyms:N-Propylpiperazine;

Chemical Property of 1-Propylpiperazine

Chemical Property:

• Vapor Pressure: 1.08mmHg at 25°C
• Refractive Index: 1.445
• Boiling Point: 176.7 °C at 760 mmHg
• Flash Point: 60.7 °C
• PSA: 15.27000
• Density: 0.868 g/cm³
• LogP: 0.56830
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-Propylpiperazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Propylpiperazine

There total 1 articles about 1-Propylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-ethoxycarbonylpiperazine (120-43-4) → 1-n-propylpiperazine (21867-64-1) + 4-propyl-piperazine-1-carboxylic acid ethyl ester (71172-70-8)

Guidance literature:

Reference yield: 97.0%

4-acetoxybenzoyl chloride (27914-73-4) + 1-n-propylpiperazine (21867-64-1) → Acetic acid 4-(4-propyl-piperazine-1-carbonyl)-phenyl ester; hydrochloride

Guidance literature:

In diethyl ether; at -15 - -10 ℃; for 0.166667h;

DOI:10.1016/0223-5234(96)85875-2

Reference yield: 85.0%

1-n-propylpiperazine (21867-64-1) + 4-Fluorobenzenesulfonyl chloride (349-88-2) → 1-(4-fluoro-benzenesulfonyl)-4-propyl-piperazine

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/jm000972h

upstream raw materials:

4-ethoxycarbonylpiperazine

Downstream raw materials:

1-<(3,4-dichlorophenyl)acetyl>-4-(1-propyl)piperazine

8-Fluoro-3-methyl-6-oxo-9-(4-propyl-piperazin-1-yl)-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid

N-(2-Allyloxy-phenyl)-N-[2-hydroxy-3-(4-propyl-piperazin-1-yl)-propyl]-methanesulfonamide; hydrochloride

N-(2-Allyloxy-phenyl)-N-[2-hydroxy-3-(4-propyl-piperazin-1-yl)-propyl]-4-methyl-benzenesulfonamide; hydrochloride

Refernces

• 1、 -. "2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use". . . Retrieved 2008/06/13.