N¹-(3-nitro-4-methoxybenzyl)-N³-methyl-6-chlorouracil

Base Information

• Chemical Name: N¹-(3-nitro-4-methoxybenzyl)-N³-methyl-6-chlorouracil
• CAS No.: 121593-89-3
• Molecular Formula: C₁₃H₁₂ClN₃O₅
• Molecular Weight: 325.708
• Mol file: 121593-89-3.mol

Synonyms:N¹-(3-nitro-4-methoxybenzyl)-N³-methyl-6-chlorouracil

Chemical Property of N¹-(3-nitro-4-methoxybenzyl)-N³-methyl-6-chlorouracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(3-nitro-4-methoxybenzyl)-N³-methyl-6-chlorouracil

There total 1 articles about N¹-(3-nitro-4-methoxybenzyl)-N³-methyl-6-chlorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.1%

3-methyl-6-chlorouracil (4318-56-3) + 4-methoxy-3-nitrobenzyl chloride (6378-19-4) → N1-(3-nitro-4-methoxybenzyl)-N3-methyl-6-chlorouracil (121593-89-3)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 - 90 ℃; for 1h;

DOI:10.1007/BF00831702

Reference yield: 94.2%

N1-(3-nitro-4-methoxybenzyl)-N3-methyl-6-chlorouracil (121593-89-3) + methylamine (74-89-5) → 1-(4-Methoxy-3-nitro-benzyl)-3-methyl-6-methylamino-1H-pyrimidine-2,4-dione (121593-82-6)

Guidance literature:

In ethanol; water; for 2h; Heating;

DOI:10.1007/BF00831702

Reference yield: 87.5%

N1-(3-nitro-4-methoxybenzyl)-N3-methyl-6-chlorouracil (121593-89-3) + ethanolamine (141-43-5) → 6-(2-Hydroxy-ethylamino)-1-(4-methoxy-3-nitro-benzyl)-3-methyl-1H-pyrimidine-2,4-dione (121593-81-5)

Guidance literature:

In ethanol; water; for 2h; Heating;

DOI:10.1007/BF00831702

upstream raw materials:

3-methyl-6-chlorouracil

4-methoxy-3-nitrobenzyl chloride

Downstream raw materials:

N¹-(3-nitro-4-methoxybenzyl)-N³-methyl-6-methoxyuracil

N¹-(3-nitro-4-methoxybenzyl)-N³-methyl-6-ethoxyuracil

6-(2-Hydroxy-ethylamino)-1-(4-methoxy-3-nitro-benzyl)-3-methyl-1H-pyrimidine-2,4-dione

6-Allylamino-1-(4-methoxy-3-nitro-benzyl)-3-methyl-1H-pyrimidine-2,4-dione

Refernces