(R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL

Base Information

• Chemical Name: (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL
• CAS No.: 159350-97-7
• Molecular Formula: C5H12O3
• Molecular Weight: 120.148
• Mol file: 159350-97-7.mol

Synonyms:1-Propanol,2-(methoxymethoxy)-, (R)-;(R)-2-(Methoxymethoxy)-1-propanol;

Chemical Property of (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL

Chemical Property:

• Vapor Pressure: 1.205mmHg at 25°C
• Refractive Index: 1.411
• Boiling Point: 153.861 °C at 760 mmHg
• PKA: 14.35±0.10(Predicted)
• Flash Point: 46.854 °C
• PSA: 49.69000
• Density: 0.987 g/cm³
• LogP: -0.27630

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-2-Methoxymethoxy-propan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 10-22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL

There total 2 articles about (R)-(-)-2-(METHYLMETHOXY)-1,2-PROPANEDIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

sodium tetrahydroborate (16940-66-2) + isobutyl (R)-2-(methoxymethoxy)propionate (159350-96-6) → (R)-2-(methoxymethoxy)-1-propanol (159350-97-7)

Guidance literature:

In methanol; water; pentane;

Reference yield: 83.0%

isobutyl (R)-2-(methoxymethoxy)propionate (159350-96-6) → (R)-2-(methoxymethoxy)-1-propanol (159350-97-7)

Guidance literature:

With lithium aluminium tetrahydride; sodium sulfate; In tetrahydrofuran;

DOI:10.1055/s-1994-25589

Reference yield: 73.0%

N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-fluoro-5-(trifluoromethyl)benzamide (1231955-35-3) + (R)-2-(methoxymethoxy)-1-propanol (159350-97-7) → N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2R)-2-(methoxymethoxy)propyl]oxy}-5-(trifluoromethyl)benzamide (1311285-20-7)

Guidance literature:

(R)-2-(methoxymethoxy)-1-propanol; With sodium t-butanolate; In tetrahydrofuran; at 5 ℃; for 0.5h;

N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-fluoro-5-(trifluoromethyl)benzamide; In tetrahydrofuran; at 0 ℃; for 4h;

upstream raw materials:

isobutyl (R)-2-(methoxymethoxy)propionate

sodium tetrahydroborate

Downstream raw materials:

(4R,5R)-5-methoxymethoxy-4-(p-methoxyphenyl)methoxy-1-hexene

(3R,4R)-4-methoxymethoxy-3-(p-methoxyphenyl)methoxypentanal

(4S,6R,7R)-6-(4-Methoxy-benzyloxy)-7-methoxymethoxy-oct-1-en-4-ol

(4S,6R,7R)-4-(3,4-dimethoxyphenyl)methoxy-7-methoxymethoxy-6-(p-methoxyphenyl)methoxy-1-octene

Refernces

• 1、 De Brabander,Vandewalle. "Bryostatins: The asymmetric synthesis of the C1-C9 and C17-C27 fragments". . p. 855 - 865. Retrieved 2007/10/02.