(1H-INDOL-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (1H-INDOL-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 819850-13-0
• Molecular Formula: C13H16 N2 O2
• Molecular Weight: 232.28
• Hs Code.: 2933990090
• Mol file: 819850-13-0.mol

Synonyms:1H-INDOL-4-YL-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER;(1H-INDOL-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property of (1H-INDOL-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 4.42E-05mmHg at 25°C
• Boiling Point: 350.4°C at 760 mmHg
• Flash Point: 165.7°C
• PSA: 54.12000
• Density: 1.216
• LogP: 3.58790
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%Min ^*data from raw suppliers

tert-Butyl1H-Indol-4-ylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1H-INDOL-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

There total 9 articles about (1H-INDOL-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

tert-butyl N-(7-bromo-1H-indol-4-yl)carbamate (1380445-23-7) + bis(pinacol)diborane (73183-34-3) → (1H-Indol-4-yl) carbamic acid tert-butyl ester (819850-13-0) + tert-butyl N-[7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indol-4-yl]carbamate

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; XPhos; In 1,4-dioxane; at 100 ℃; for 2h;

Reference yield: 28.5%

4-amino-1H-indole (5192-23-4) + di-tert-butyl dicarbonate (24424-99-5) → (1H-Indol-4-yl) carbamic acid tert-butyl ester (819850-13-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 13h;

Reference yield: 21.9%

tert-butyl N-(7-bromo-1H-indol-4-yl)carbamate (1380445-23-7) → (1H-Indol-4-yl) carbamic acid tert-butyl ester (819850-13-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; bis(pinacol)diborane; XPhos; In 1,4-dioxane; at 100 ℃; for 2h; Inert atmosphere;

upstream raw materials:

4-amino-1H-indole

di-tert-butyl dicarbonate

4-bromo-3-nitroaniline

(4-bromo-3-nitrophenyl)carbamic acid tert-butyl ester

Downstream raw materials:

6-((4-tert-butoxycarbonylamino)-1H-indol-3-yl)-2,6-dimethylcyclohex-2-ene-1,4-dione

Refernces

• 1、 -. "Small molecule compound". . . Retrieved 2020/01/12.
• 2、 -. "Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof". Page/Page column 7-8. . Retrieved 2008/06/13.