3-PYRIMIDIN-4-YL-PROPIONIC ACID

Base Information

• Chemical Name: 3-PYRIMIDIN-4-YL-PROPIONIC ACID
• CAS No.: 819850-17-4
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.153
• Hs Code.: 2933599090
• Mol file: 819850-17-4.mol

Synonyms:3-Pyrimidin-4-ylpropanoic acid;3-Pyrimidin-4-yl-propionic acid;3-(Pyrimidin-4-yl)propanoic acid;

Chemical Property of 3-PYRIMIDIN-4-YL-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 0.00013mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 320.6 °C at 760 mmHg
• Flash Point: 147.7 °C
• PSA: 63.08000
• Density: 1.269 g/cm³
• LogP: 0.49380

Purity/Quality:

90.0%Min ^*data from raw suppliers

3-(pyrimidin-4-yl)propanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PYRIMIDIN-4-YL-PROPIONIC ACID

There total 2 articles about 3-PYRIMIDIN-4-YL-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-pyrimidin-4-yl-acrylic acid → 3-pyrimidin-4-yl-propionic acid (819850-17-4)

Guidance literature:

With sodium hydroxide; nickel; Hydrogenation;

DOI:10.1021/ja01164a061

Reference yield:

1,1,1-trichloro-3-pyrimidin-4-yl-propan-2-ol (909084-42-0) → 3-pyrimidin-4-yl-propionic acid (819850-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic NaOH

2: Raney nickel; aq. NaOH solution / Hydrogenation

With sodium hydroxide; nickel;

DOI:10.1021/ja01164a061

Reference yield:

3-pyrimidin-4-yl-propionic acid (819850-17-4) + 2-chloro-ethanol (107-07-3) → trimethyl-[2-(3-pyrimidin-4-yl-propionyloxy)-ethyl]-ammonium; dipicrate (123936-02-7)

Guidance literature:

aufeinanderfolgendes Behandeln mit Picrinsaeure ,Trimethylamin und wieder mit Picrinsaeure;

upstream raw materials:

1,1,1-trichloro-3-pyrimidin-4-yl-propan-2-ol

Downstream raw materials:

trimethyl-[2-(3-pyrimidin-4-yl-propionyloxy)-ethyl]-ammonium; dipicrate