5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE

Base Information

• Chemical Name: 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE
• CAS No.: 7195-78-0
• Molecular Formula: C7H4 Cl N O5
• Molecular Weight: 217.565
• Hs Code.: 2918290090
• Mol file: 7195-78-0.mol

Synonyms:Salicylicacid, 5-chloro-3-nitro- (7CI,8CI); 5-Chloro-2-hydroxy-3-nitrobenzoic acid;5-Chloro-3-nitrosalicylic acid; NSC 37272

Chemical Property of 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE

Chemical Property:

• Vapor Pressure: 1.37E-05mmHg at 25°C
• Melting Point: 132-135 °C(lit.)
• Boiling Point: 357oC at 760 mmHg
• Flash Point: 169.7oC
• PSA: 83.12000
• Density: 1.527g/cm3
• LogP: 2.67960

Purity/Quality:

98% ^*data from raw suppliers

5-Chloro-2-hydroxy-3-nitrobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE

There total 5 articles about 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-chloro-2-hydroxybenzoic acid (321-14-2) → 5-chloro-2-hydroxy-3-nitrobenzoic acid (7195-78-0)

Guidance literature:

With sulfuric acid; nitric acid; at 20 ℃;

DOI:10.1007/s00044-015-1325-9

Reference yield:

5-chloro-2-hydroxybenzoic acid (321-14-2) → 4-chloro-2,6-dinitrophenol (88-87-9) + 5-chloro-2-hydroxy-3-nitrobenzoic acid (7195-78-0)

Guidance literature:

With nitric acid;

Reference yield:

5-chloro-2-hydroxybenzoic acid (321-14-2) + nitric acid (7697-37-2,78989-43-2) → 4-chloro-2,6-dinitrophenol (88-87-9) + 5-chloro-2-hydroxy-3-nitrobenzoic acid (7195-78-0)

Guidance literature:

DOI:10.1359/jbmr.2001.16.3.501

upstream raw materials:

5-chloro-2-hydroxybenzoic acid

nitric acid

acetic acid

Downstream raw materials:

3-aminosalicylic acid

ethyl 3-aminio-5-chloro-2-hydroxybenzoate

3-amino-5-chloro-2-hydroxybenzoic acid

Refernces

• 1、 -. "3-process for the preparation of amino-salicylic acid". Paragraph 0024-0026. . Retrieved 2016/10/08.
• 2、 -. "Fungicidal compositions and methods, and compounds and methods for the preparation thereof". . . Retrieved 2008/06/13.