p-trifluoromethyl cinnamyl chloride

Base Information

• Chemical Name: p-trifluoromethyl cinnamyl chloride
• CAS No.: 103977-75-9
• Molecular Formula: C₁₀H₈ClF₃
• Molecular Weight: 220.622
• Mol file: 103977-75-9.mol

Synonyms:p-trifluoromethyl cinnamyl chloride

Chemical Property of p-trifluoromethyl cinnamyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-trifluoromethyl cinnamyl chloride

There total 3 articles about p-trifluoromethyl cinnamyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-(trifluoromethyl)cinnamyl alcohol (180635-56-7) → p-trifluoromethyl cinnamyl chloride (103977-75-9)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/ejoc.201900431

Reference yield:

4-(trifluoromethyl)cinnamic acid (16642-92-5,87212-84-8,2062-26-2) → p-trifluoromethyl cinnamyl chloride (103977-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 0 - 80 °C

2: diisobutylaluminium hydride / tetrahydrofuran / -78 - 20 °C

3: thionyl chloride / dichloromethane / 0 - 20 °C

With thionyl chloride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201900431

Reference yield:

methyl 4-trifluoromethylcinnamate (79947-88-9) → p-trifluoromethyl cinnamyl chloride (103977-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran / -78 - 20 °C

2: thionyl chloride / dichloromethane / 0 - 20 °C

With thionyl chloride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201900431

upstream raw materials:

4-(trifluoromethyl)cinnamic acid

methyl 4-trifluoromethylcinnamate

p-(trifluoromethyl)cinnamyl alcohol

Downstream raw materials:

(E)-4-((p-trifluoromethyl)phenyl)but-3-enoic acid

Refernces