4-(Trifluoromethyl)phenylhydrazine hydrochloride

Base Information

• Chemical Name: 4-(Trifluoromethyl)phenylhydrazine hydrochloride
• CAS No.: 2923-56-0
• Molecular Formula: C7H8ClF3N2
• Molecular Weight: 212.602
• Hs Code.: 29280000
• Mol file: 2923-56-0.mol

Synonyms:Hydrazine,[4-(trifluoromethyl)phenyl]-, monohydrochloride (9CI);

Chemical Property of 4-(Trifluoromethyl)phenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0674mmHg at 25°C
• Melting Point: 200 °C
• Boiling Point: 230 °C at 760 mmHg
• Flash Point: 92.9 °C
• PSA: 38.05000
• Density: 1.258 g/cm³
• LogP: 3.56630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(Trifluoromethyl)phenylhydrazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Trifluoromethyl)phenylhydrazine hydrochloride

There total 3 articles about 4-(Trifluoromethyl)phenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

→ (Z)-3,6-Dihydro[1,2,3]triazolo[4,5-e]indole-7,8-dione 8-{N-[4-(trifluoromethyl)phenyl]hydrazone} (297757-07-4) + 4-(trifluoromethyl)phenylhydrazine hydrochloride (2923-56-0)

Guidance literature:

Reference yield:

4-trifluoromethylphenylamine (455-14-1) → 4-(trifluoromethyl)phenylhydrazine hydrochloride (2923-56-0)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; sodium nitrite; Yield given. Multistep reaction; 1.) below 3 deg C, 2.) 0 deg C, 1 h;

DOI:10.1021/jo00113a022

Reference yield:

p-trifluoromethylphenyl bromide (402-43-7) → 4-(trifluoromethyl)phenylhydrazine hydrochloride (2923-56-0)

Guidance literature:

p-trifluoromethylphenyl bromide; With nickel(II) bromide trihydrate; t-butoxycarbonylhydrazine; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 120 ℃; for 0.166667h; Irradiation; Flow reactor;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/d0cc06787c

upstream raw materials:

4-trifluoromethylphenylamine

p-trifluoromethylphenyl bromide

Downstream raw materials:

C₁₇H₁₀F₃N₃O

1-(4-trifluoromethylphenyl)-1,5,6,7-tetrahydroindazol-4-one

ethyl 3-(4-trifluoromethylphenyl)-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-dien-5-carboxylate

C₂₀H₁₇F₃N₂O₂

Refernces

• 1、 Mata, Alejandro,Tran, Duc N.,Weigl, Ulrich,Williams, Jason D.,Kappe, C. Oliver. "Continuous flow synthesis of arylhydrazines: via nickel/photoredox coupling of tert -butyl carbazate with aryl halides". supporting information. p. 14621 - 14624. Retrieved 2020/12/02.
• 2、 Jin, Xiao-Yan,Zhang, Kang-Ping,Chen, Hao,Miao, Ting-Ting,Wang, Shi-Fa,Gu, Wen. "Synthesis, in vitro Antimicrobial, and Cytotoxic Activities of New 1,3,4-Oxadiazin-5(6H)-one Derivatives from Dehydroabietic Acid". . p. 538 - 547. Retrieved 2018/06/11.