2'-DEOXYPSEUDOISOCYTIDINE

Base Information

• Chemical Name: 2'-DEOXYPSEUDOISOCYTIDINE
• CAS No.: 65358-18-1
• Molecular Formula: C₉H₁₃N₃O₄
• Molecular Weight: 227.22
• Mol file: 65358-18-1.mol

Synonyms:2'-Deoxypseudoisocytidine

Chemical Property of 2'-DEOXYPSEUDOISOCYTIDINE

Chemical Property:

• PSA: 121.46000
• LogP: -0.88350

Purity/Quality:

97% ^*data from raw suppliers

2'-Deoxypseudoisocytidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-DEOXYPSEUDOISOCYTIDINE

There total 20 articles about 2'-DEOXYPSEUDOISOCYTIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5'-O-Trityl-2'-deoxy-ψ-isocytidine (78064-67-2) → 2'-Deoxy-ψ-isocytidine (65358-18-1)

Guidance literature:

With formic acid; for 0.05h; Ambient temperature;

DOI:10.1021/jo00331a005

Reference yield: 71.0%

N-{5-[(2’R,4’S,5’R)-4’-hydroxy-5’-(hydroxymethyl)tetrahydrofuran-2’-yl]-6-oxo-1,6-dihydropyrimidin-2-yl}acetamide → 2-amino-5-[(2’R,4’S,5’R)-4’-hydroxy-5’-(hydroxymethyl)tetrahydrofuran-2’-yl]pyrimidin-4(3H)-one (65358-18-1)

Guidance literature:

With ammonia; In methanol; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1002/open.201700019

Reference yield: 40.0%

2'-deoxy-3',5'-O-(tetraisopropyldisiloxanyl)pseudoisocytidine (80545-55-7) → 2'-deoxypseudoisocytidine (65358-18-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/jo00342a022

upstream raw materials:

1,3-Dimethyl-2'-deoxypseudouridine

5'-O-Trityl-2'-deoxy-ψ-isocytidine

1-methyl-2'-deoxy-5'-O-tritylpseudouridine

1,3-Dimethyl-2'-deoxy-5'-O-tritylpseudouridine

Refernces

• 1、 -. "Modified oligonucleotides and applications thereof". . . Retrieved 2008/06/13.
• 2、 Matsuda,Chu,Reichman,et al.. "Nucleosides. 120. Syntheses of 2'-deoxy-ψ-isocytidine and 2'-deoxy-1-methyl-ψ-uridine from ψ-uridine". . p. 3603 - 3609. Retrieved 2007/10/02.