4-(DIFLUOROMETHOXY)BENZYL ALCOHOL

Base Information

• Chemical Name: 4-(DIFLUOROMETHOXY)BENZYL ALCOHOL
• CAS No.: 659-33-6
• Molecular Formula: C8H8 F2 O2
• Molecular Weight: 174.147
• Hs Code.: 2909309090
• Mol file: 659-33-6.mol

Synonyms:1-Difluormethoxy-4-methoxy-benzol;4-Methoxy-phenyl-difluormethyl-aether;difluoromethyl 4-methoxyphenyl ether;RARECHEM AL BD 0279;

Chemical Property of 4-(DIFLUOROMETHOXY)BENZYL ALCOHOL

Chemical Property:

• Melting Point: -39 °C
• Boiling Point: 242.7 ºCat 760 mmHg
• Flash Point: 119.1 ºC
• PSA: 29.46000
• Density: 1.257 g/cm³
• LogP: 1.78030

Purity/Quality:

99% ^*data from raw suppliers

4-(Difluoromethoxy)benzylalcohol 95% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(DIFLUOROMETHOXY)BENZYL ALCOHOL

There total 11 articles about 4-(DIFLUOROMETHOXY)BENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

trifluoromethan (75-46-7) + 4-methoxy-phenol (150-76-5) → 4-methoxy-1-(difluoro-methoxy)benzene (659-33-6)

Guidance literature:

4-methoxy-phenol; With water; potassium hydroxide; for 0.5h; under 760.051 Torr; Inert atmosphere;

trifluoromethan; In acetonitrile; at 20 ℃; under 760.051 Torr; Solvent; Temperature; Inert atmosphere;

DOI:10.1021/jo401392f

Reference yield: 85.0%

[bromo(difluoro)methyl]-trimethyl-silane (115262-01-6) + 4-methoxy-phenol (150-76-5) → 4-methoxy-1-(difluoro-methoxy)benzene (659-33-6)

Guidance literature:

With potassium hydroxide; In dichloromethane; water; at 0 ℃; for 0.5h;

DOI:10.1002/anie.201306703

Reference yield: 63.0%

diethyl (bromodifluoromethyl)phosphonate (65094-22-6) + 4-methoxy-phenol (150-76-5) → 4-methoxy-1-(difluoro-methoxy)benzene (659-33-6)

Guidance literature:

With potassium hydroxide; In water; acetonitrile; at -78 - 20 ℃; for 0.333333h;

DOI:10.1016/j.tet.2009.04.082

upstream raw materials:

Chlorodifluoromethane

4-methoxy-phenol

diethyl (bromodifluoromethyl)phosphonate

p-chlorophenyl chlorodifluoromethyl sulfone

Refernces

• 1、 Zafrani, Yossi,Yeffet, Dina,Sod-Moriah, Gali,Berliner, Anat,Amir, Dafna,Marciano, Daniele,Gershonov, Eytan,Saphier, Sigal. "Difluoromethyl bioisostere: Examining the lipophilic hydrogen bond donor concept". . p. 797 - 804. Retrieved 2017/02/05.
• 2、 Wang, Fei,Li, Lingchun,Ni, Chuanfa,Hu, Jinbo. "Deoxygenative gem-difluoroolefination of carbonyl compounds with (chlorodifluoromethyl)trimethylsilane and triphenylphosphine". supporting information. p. 344 - 351. Retrieved 2014/03/21.