2-(AMINOMETHYL)-1-METHYLIMIDAZOLE

Base Information

• Chemical Name: 2-(AMINOMETHYL)-1-METHYLIMIDAZOLE
• CAS No.: 124312-73-8
• Molecular Formula: C5H9N3
• Molecular Weight: 111.147
• Hs Code.: 2933290090
• Mol file: 124312-73-8.mol

Synonyms:(1-Methyl-1H-imidazol-2-yl)methanamine;1-Methyl-2-aminomethylimidazo;2-Aminomethyl-1-methylimidazole;C-(1-Methyl-1H-imidazol-2-yl)methylamine;[(1-Methyl-1H-imidazol-2-yl)methyl]amine;

Chemical Property of 2-(AMINOMETHYL)-1-METHYLIMIDAZOLE

Chemical Property:

• Vapor Pressure: 0.0166mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 255.1 °C at 760 mmHg
• PKA: 8.03±0.40(Predicted)
• Flash Point: 108.1 °C
• PSA: 29.85000
• Density: 1.16 g/cm³
• LogP: 0.53480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

(1-Methyl-1h-imidazol-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: C:Corrosive
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(AMINOMETHYL)-1-METHYLIMIDAZOLE

There total 4 articles about 2-(AMINOMETHYL)-1-METHYLIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-methyl-1H-imidazole-2-carbaldehyde O-benzyloxime (1430413-09-4) → C-(1-Methyl-1H-imidazol-2-yl)-methylamine (124312-73-8)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 24h; under 15201 Torr; Autoclave;

DOI:10.1016/j.bmc.2013.01.063

Reference yield: 90.0%

N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → C-(1-Methyl-1H-imidazol-2-yl)-methylamine (124312-73-8)

Guidance literature:

N-methyl-2-imidazolcarboxaldehyde; With pyridine; hydroxylamine hydrochloride; In ethanol; at 50 ℃;

With acetic acid; zinc; Further stages.;

DOI:10.1016/j.tetlet.2004.05.143

Reference yield: 72.0%

→ C-(1-Methyl-1H-imidazol-2-yl)-methylamine (124312-73-8)

Guidance literature:

upstream raw materials:

N-methyl-2-imidazolcarboxaldehyde

2-(1-methyl-1H-imidazol-2-ylmethyl)-isoindol-1,3-dione

1-methyl-1H-imidazole-2-carbaldehyde O-benzyloxime

Downstream raw materials:

4-amino-3,5-dichloro-N-[(1-methyl-1H-imidazol-2-yl)methyl]benzenesulfonamide

1-(3-isopropylamino-benzyl)-3-(1-methyl-1H-imidazol-2-ylmethyl)-urea

Refernces

• 1、 Ferri, Nicola,Cazzaniga, Stefano,Mazzarella, Luca,Curigliano, Giuseppe,Lucchini, Giorgio,Zerla, Daniele,Gandolfi, Raffaella,Facchetti, Giorgio,Pellizzoni, Michela,Rimoldi, Isabella. "Cytotoxic effect of (1-methyl-1H-imidazol-2-yl)-methanamine and its derivatives in PtII complexes on human carcinoma cell lines: A comparative study with cisplatin". . p. 2379 - 2386. Retrieved 2013/05/09.
• 2、 -. "Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use". Page 32. . Retrieved 2010/02/03.