1,2,3,9-TETRAHYDRO-9-METHTYL-3-METHYLENE-4H-CARBAZOL-4-ONE

Base Information

• Chemical Name: 1,2,3,9-TETRAHYDRO-9-METHTYL-3-METHYLENE-4H-CARBAZOL-4-ONE
• CAS No.: 99614-64-9
• Molecular Formula: C14H13NO
• Molecular Weight: 211.263
• Hs Code.: 2933990090
• Mol file: 99614-64-9.mol

Synonyms:1,2,3,4-Tetrahydro-9-methyl-3-methylene-9H-carbazol-4-one;

Chemical Property of 1,2,3,9-TETRAHYDRO-9-METHTYL-3-METHYLENE-4H-CARBAZOL-4-ONE

Chemical Property:

• Appearance/Colour: white or almost white power
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.633
• Boiling Point: 393.56 °C at 760 mmHg
• Flash Point: 191.82 °C
• PSA: 22.00000
• Density: 1.18 g/cm³
• LogP: 2.86340
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-43
• Safety Statements: 36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one is an impurity of Ondansetron (O655000).

Technology Process of 1,2,3,9-TETRAHYDRO-9-METHTYL-3-METHYLENE-4H-CARBAZOL-4-ONE

There total 24 articles about 1,2,3,9-TETRAHYDRO-9-METHTYL-3-METHYLENE-4H-CARBAZOL-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one (27387-31-1,808754-65-6) + bis-(dimethylamino)methane (51-80-9) → 9-methyl-3-methylene-1,2,3,9-tetrahydro-4H-carbazol-4-one (99614-64-9)

Guidance literature:

9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one; bis-(dimethylamino)methane; With acetyl chloride; In acetonitrile; for 2h; Heating / reflux;

With sodium acetate; In acetonitrile; for 6.5h; Product distribution / selectivity; Heating / reflux;

Reference yield: 90.0%

9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one (27387-31-1,808754-65-6) + 1,1'-methylenebis(3-methylpiperidine) (68922-17-8) → 9-methyl-3-methylene-1,2,3,9-tetrahydro-4H-carbazol-4-one (99614-64-9)

Guidance literature:

9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one; 1,1'-methylenebis(3-methylpiperidine); With acetic anhydride; acetyl chloride; In acetonitrile; for 1h; Heating / reflux;

With sodium acetate; In acetonitrile; Product distribution / selectivity; Heating / reflux;

Reference yield: 90.0%

di(N-piperidinyl)methane (880-09-1) + 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one (27387-31-1,808754-65-6) → 9-methyl-3-methylene-1,2,3,9-tetrahydro-4H-carbazol-4-one (99614-64-9)

Guidance literature:

di(N-piperidinyl)methane; 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one; With acetic anhydride; acetyl chloride; In acetonitrile; for 1h; Heating / reflux;

With sodium acetate; In acetonitrile; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

formaldehyd

9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one

3-[(dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one

1,3,5-trimethyl-1,3,5-triazacyclohexane

Downstream raw materials:

ondanserton

Refernces

• 1、 -. "Preparation method of ondansetron impurity A". Paragraph 0025; 0026; 0027; 0028. . Retrieved 2019/01/08.
• 2、 -. "A ONE-POT PROCESS FOR THE PREPARATION OF ANTIEMETIC AGENT, 1,2,3,9-TETRAHYDRO-9-METHYL-3[(2-METHYL)-1H-IMIDAZOLE-1-YL)METHYL]-4H-CARBAZOL-4-O". Page/Page column 18-19. . Retrieved 2008/06/13.