2-Amino-5-bromo-3-iodopyridine

Base Information

• Chemical Name: 2-Amino-5-bromo-3-iodopyridine
• CAS No.: 381233-96-1
• Molecular Formula: C5H4BrIN2
• Molecular Weight: 298.909
• Hs Code.: 29333990
• European Community (EC) Number: 622-993-5
• DSSTox Substance ID: DTXSID90363974
• Nikkaji Number: J3.270.796C
• Wikidata: Q72438595
• Mol file: 381233-96-1.mol

Synonyms:2-Amino-5-bromo-3-iodopyridine;381233-96-1;5-Bromo-3-iodopyridin-2-amine;5-bromo-3-iodo-pyridin-2-ylamine;2-Amino-3-iodo-5-bromopyridine;2-Pyridinamine, 5-bromo-3-iodo-;MFCD06659000;2-Amine-5-bromo-3-iodopyridine;SCHEMBL402578;SCHEMBL4618937;5-Bromo-3-iodopyridine-2-amine;DTXSID90363974;BCP23244;BBL103663;STL557473;AKOS005257759;AB25852;AC-9126;CS-W003313;GS-6810;2-Amino-5-bromo-3-iodopyridine, 97%;SY028356;A6468;AM20051129;FT-0630213;EN300-86176;Q-103389

Chemical Property of 2-Amino-5-bromo-3-iodopyridine

Chemical Property:

• Appearance/Colour: Brown powder
• Vapor Pressure: 0.000691mmHg at 25°C
• Melting Point: 111-112 °C
• Refractive Index: 1.73
• Boiling Point: 308.2 °C at 760 mmHg
• PKA: 2.25±0.49(Predicted)
• Flash Point: 140.2 °C
• PSA: 38.91000
• Density: 2.426 g/cm³
• LogP: 2.61210
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 297.86026
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

98%, ^*data from raw suppliers

2-AMINO-5-BROMO-3-IODOPYRIDINE ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36:37/38-41-37/38-22
• Safety Statements: 26-36/37/39-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1I)N)Br

Technology Process of 2-Amino-5-bromo-3-iodopyridine

There total 6 articles about 2-Amino-5-bromo-3-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-bromo-2-pyridylamine (1072-97-5) → 2-amino-3-iodo-5-bromopyridine (381233-96-1)

Guidance literature:

With iodine; periodic acid; In acetonitrile; Inert atmosphere;

DOI:10.1002/anie.201303490

Reference yield: 91.0%

3-iodo-2-aminopyridine (104830-06-0) → 2-amino-3-iodo-5-bromopyridine (381233-96-1)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ol403390m

Reference yield: 76.0%

5-bromo-2-pyridylamine (1072-97-5) + periodic acid hydrate → 2-amino-3-iodo-5-bromopyridine (381233-96-1)

Guidance literature:

With sodium hydroxide; sulfuric acid; iodine; In diethyl ether; water; acetic acid; ethyl acetate;

upstream raw materials:

5-bromo-2-pyridylamine

C₉H₈BrIN₂O₂

3-iodo-2-aminopyridine

2-aminopyridine

Downstream raw materials:

5-(2-amino-5-bromo-pyridin-3-yl)-3-[1-(2-chloro-phenyl)-ethoxy]-thiophene-2-carboxylic acid methyl ester

5-bromo-3-iodo-1,2-dihydropyridin-2-one

5-bromo-3-(3-methoxyphenyl)-2-pyridinamine

5-bromo-3-(3,4-dimethoxy-phenyl)-pyridin-2-ylamine

Refernces

• 1、 -. "Preparation method for 5-bromo-7-azindole". Page/Page column 5-7. . Retrieved 2019/04/17.
• 2、 -. "2 - Amino -3 - iodo -5 - bromo pyridine synthesis method". Paragraph 0017-0027; 0029-0032. . Retrieved 2018/09/08.