2,2-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane

Base Information

• Chemical Name: 2,2-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane
• CAS No.: 116673-45-1
• Molecular Formula: C₂₁H₂₆O₈
• Molecular Weight: 406.433
• DSSTox Substance ID: DTXSID00700290
• Wikidata: Q82631549
• Mol file: 116673-45-1.mol

Synonyms:SCHEMBL7212713;DTXSID00700290;2,2-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane

Chemical Property of 2,2-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane

Chemical Property:

• Refractive Index: 1.53
• Boiling Point: 517.422 °C at 760 mmHg
• Flash Point: 208.333 °C
• PSA: 73.84000
• Density: 1.19 g/cm³
• LogP: 3.52490
• Solubility.: ≤35mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 8
• Exact Mass: 406.16276778
• Heavy Atom Count: 29
• Complexity: 431

Purity/Quality:

98%min ^*data from raw suppliers

Bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C2(OCCO2)C3=CC(=C(C(=C3)OC)OC)OC
• Uses: A potent and selective platlet activating factor

Technology Process of 2,2-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane

There total 2 articles about 2,2-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) + 1-(3,4,5-trimethoxyphenyl)-1,2-dihydroxyethane (116673-46-2) → (+/-)-trans-2,5-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane (116673-45-1,116673-47-3) + (2R,4S)-2,4-Bis-(3,4,5-trimethoxy-phenyl)-[1,3]dioxolane (116673-45-1,116673-47-3)

Guidance literature:

With camphor-10-sulfonic acid; In benzene; at 40 ℃; Yield given. Yields of byproduct given;

DOI:10.1016/0040-4039(88)85042-1

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) + 1-(3,4,5-trimethoxyphenyl)-1,2-dihydroxyethane (116673-46-2) → (+/-)-trans-2,5-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane (116673-45-1,116673-47-3) + (2R,4S)-2,4-Bis-(3,4,5-trimethoxy-phenyl)-[1,3]dioxolane (116673-45-1,116673-47-3)

Guidance literature:

With camphor-10-sulfonic acid; In benzene; at 40 ℃; Yield given. Yields of byproduct given;

DOI:10.1016/0040-4039(88)85042-1

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

1-(3,4,5-trimethoxyphenyl)-1,2-dihydroxyethane

Refernces