(4-PYRROLIDIN-1-YLPHENYL)BORONIC ACID

Base Information

• Chemical Name: (4-PYRROLIDIN-1-YLPHENYL)BORONIC ACID
• CAS No.: 229009-41-0
• Molecular Formula: C10H14BNO2
• Molecular Weight: 191.038
• Hs Code.: 2933998090
• Mol file: 229009-41-0.mol

Synonyms:4-Pyrrolidinophenylboronic acid;[4-(Pyrrolidin-1-yl)phenyl]boronic acid;

Chemical Property of (4-PYRROLIDIN-1-YLPHENYL)BORONIC ACID

Chemical Property:

• Boiling Point: 403.2 °C at 760 mmHg
• Flash Point: 197.7 °C
• PSA: 43.70000
• Density: 1.19 g/cm³
• LogP: 0.03160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(pyrrolidin-1-yl)phenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-PYRROLIDIN-1-YLPHENYL)BORONIC ACID

There total 1 articles about (4-PYRROLIDIN-1-YLPHENYL)BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

→ (4-(pyrrolidin-1-yl)phenyl) boronic acid (229009-41-0)

Guidance literature:

Reference yield: 92.78%

6-bromo-3-iodo-2-(naphthalen-1-ylmethoxy)quinoline + (4-(pyrrolidin-1-yl)phenyl) boronic acid (229009-41-0) → 6-bromo-2-(naphthalen-1-ylmethoxy)-3-(4-(pyrrolidin-1-yl)phenyl)quinoline

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; toluene; at 80 ℃; for 10h;

Reference yield: 77.0%

(4-(pyrrolidin-1-yl)phenyl) boronic acid (229009-41-0) + methyl 2-bromo-6,7-dihydro-5H-benzocycloheptene-8-carboxylate (229007-63-0) → 3-(4-pyrrolidin-1-yl-phenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid methyl ester (229008-36-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; Heating;

DOI:10.1021/jm9906264

Downstream raw materials:

3-(4-pyrrolidin-1-yl-phenyl)-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid methyl ester

1-(4-bromo-phenyl)-pyrrolidine

C₂₀H₂₀N₄O

C₁₉H₁₇NO₂

Refernces