ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate

Base Information

• Chemical Name: ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate
• CAS No.: 1035404-17-1
• Molecular Formula: C₁₉H₂₀ClNO₄
• Molecular Weight: 361.825
• Mol file: 1035404-17-1.mol

Synonyms:ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate

Chemical Property of ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(2-(2-(4-chlorophenoxy)phenyl)-N-methylacetamido)acetate 95.86% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate

There total 3 articles about ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-(p-chlorophenoxy)phenylacetic acid (25563-04-6) + sarcosine ethyl ester hydrochloride (52605-49-9) → ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate (1035404-17-1)

Guidance literature:

o-(p-chlorophenoxy)phenylacetic acid; With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 40 - 50 ℃;

sarcosine ethyl ester hydrochloride; With triethylamine; In N,N-dimethyl-formamide; toluene; at 0 - 30 ℃; Product distribution / selectivity;

Reference yield:

2'-chloro-benzeneacetic acid (2444-36-2) → ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate (1035404-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; copper / o-xylene / 25 - 30 °C / Reflux

2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 40 - 50 °C

2.2: 0 - 30 °C

With thionyl chloride; copper; potassium carbonate; In o-xylene; N,N-dimethyl-formamide; toluene;

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) → ethyl N-[2-[2-(4-chlorophenoxy)phenyl]acetyl]-N-methylglycinate (1035404-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; copper / o-xylene / 25 - 30 °C / Reflux

2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 40 - 50 °C

2.2: 0 - 30 °C

With thionyl chloride; copper; potassium carbonate; In o-xylene; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2'-chloro-benzeneacetic acid

4-chloro-phenol

o-(p-chlorophenoxy)phenylacetic acid

sarcosine ethyl ester hydrochloride

Downstream raw materials:

asenapine

trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate

5-chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino [4,5-c]pyrrole-1-one

trans-11-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one

Refernces