Technology Process of 5-bromo-5-cyclohexylidene-2-methylenepentanenitrile
There total 3 articles about 5-bromo-5-cyclohexylidene-2-methylenepentanenitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile);
In
benzene;
at 80 ℃;
for 1h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol201395p
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide / dichloromethane / 24 h / 20 °C
2: n-butyl magnesium bromide / tetrahydrofuran / 2 h / 20 °C
3: 2,2'-azobis(isobutyronitrile) / benzene / 1 h / 80 °C / Inert atmosphere
With
n-butyl magnesium bromide; 2,2'-azobis(isobutyronitrile); N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide;
In
tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ol201395p
- Guidance literature:
-
Multi-step reaction with 2 steps
1: n-butyl magnesium bromide / tetrahydrofuran / 2 h / 20 °C
2: 2,2'-azobis(isobutyronitrile) / benzene / 1 h / 80 °C / Inert atmosphere
With
n-butyl magnesium bromide; 2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; benzene;
DOI:10.1021/ol201395p
