(S)-N-benzyloxycarbonyl-3-trifluoroacetoxypyrrolidine

Base Information

• Chemical Name: (S)-N-benzyloxycarbonyl-3-trifluoroacetoxypyrrolidine
• CAS No.: 960508-13-8
• Molecular Formula: C₁₄H₁₄F₃NO₄
• Molecular Weight: 317.265
• Mol file: 960508-13-8.mol

Synonyms:(S)-N-benzyloxycarbonyl-3-trifluoroacetoxypyrrolidine

Chemical Property of (S)-N-benzyloxycarbonyl-3-trifluoroacetoxypyrrolidine

Chemical Property:

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Technology Process of (S)-N-benzyloxycarbonyl-3-trifluoroacetoxypyrrolidine

There total 1 articles about (S)-N-benzyloxycarbonyl-3-trifluoroacetoxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

sodium 2,2,2-trifluoroacetate (2923-18-4) + (3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester (100858-33-1) → (S)-N-benzyloxycarbonyl-3-trifluoroacetoxypyrrolidine (960508-13-8)

Guidance literature:

sodium 2,2,2-trifluoroacetate; With 2,2-difluoro-1,3-dimethyl-imidazolidine; In toluene; at 0 - 20 ℃; for 1h;

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester; In toluene; at 0 - 50 ℃; for 3h; Product distribution / selectivity;

Reference yield:

(S)-N-benzyloxycarbonyl-3-trifluoroacetoxypyrrolidine (960508-13-8) → (S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester (100858-32-0)

Guidance literature:

With sodium hydroxide; water; In toluene; at 20 ℃; for 0.5h; Product distribution / selectivity;

upstream raw materials:

sodium 2,2,2-trifluoroacetate

(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

Downstream raw materials:

(S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester

Refernces