γ-(carbamic acid benzyl ester)-ε-caprolactone

Base Information

• Chemical Name: γ-(carbamic acid benzyl ester)-ε-caprolactone
• CAS No.: 1192764-38-7
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.293
• Mol file: 1192764-38-7.mol

Synonyms:γ-(carbamic acid benzyl ester)-ε-caprolactone

Chemical Property of γ-(carbamic acid benzyl ester)-ε-caprolactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of γ-(carbamic acid benzyl ester)-ε-caprolactone

There total 6 articles about γ-(carbamic acid benzyl ester)-ε-caprolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyl N-(4-oxocyclohexyl)carbamate (16801-63-1) → γ-(carbamic acid benzyl ester)-ε-caprolactone (1192764-38-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 14h; Cooling with ice;

DOI:10.1016/j.reactfunctpolym.2010.03.008

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → γ-(carbamic acid benzyl ester)-ε-caprolactone (1192764-38-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water

2: Jones reagent

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane

With Jones reagent; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;

DOI:10.1039/c1jm10142k

Reference yield:

trans-4-(benzyloxycarbonylamino)cyclohexanol → γ-(carbamic acid benzyl ester)-ε-caprolactone (1192764-38-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Jones reagent / acetone / 20 °C / Cooling with ice

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 20 °C / Cooling with ice

With Jones reagent; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone; 2: Baeyer-Villiger oxidation;

DOI:10.1016/j.reactfunctpolym.2010.03.008

upstream raw materials:

p-hydroxycyclohexylamine

benzyl N-(4-oxocyclohexyl)carbamate

(trans)-(4-hydroxy-cyclohexyl)-carbamic acid benzyl ester

benzyl chloroformate

Refernces

• 1、 Yan, Jinliang,Zhang, Yi,Xiao, Yan,Zhang, Yan,Lang, Meidong. "Novel poly(ε-caprolactone)s bearing amino groups: Synthesis, characterization and biotinylation". . p. 400 - 407. Retrieved 2010.