ACETYL CHLORIDE, [1-14C]

Base Information

• Chemical Name: ACETYL CHLORIDE, [1-14C]
• CAS No.: 676-77-7
• Molecular Formula: C2H3 Cl O
• Molecular Weight: 80.4872
• Mol file: 676-77-7.mol

Synonyms:ACETYL CHLORIDE, [1-14C];[1-14C]ACETYL CHLORIDE;acetyl chloride-carbonyl-14C

Chemical Property of ACETYL CHLORIDE, [1-14C]

Chemical Property:

• PSA: 17.07000
• LogP: 0.77170

Purity/Quality:

98% ^*data from raw suppliers

ACETYL CHLORIDE[1-14C] 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ACETYL CHLORIDE, [1-14C]

There total 2 articles about ACETYL CHLORIDE, [1-14C] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[1-14C]acetic acid sodium salt (993-04-4) → [1-14C]acetyl chloride (676-77-7)

Guidance literature:

With Phthaloyl dichloride; at 150 ℃; for 3h;

DOI:10.1002/(SICI)1099-1344(199902)42:2<129::AID-JLCR174>3.0.CO;2-O

Reference yield:

→ [1-14C]acetyl chloride (676-77-7)

Guidance literature:

DOI:10.1002/hlca.19730560631 DOI:10.1002/jlcr.2580130110 DOI:10.1002/jlcr.2590010310 DOI:10.1021/jf60148a015 DOI:10.1016/0040-4020(67)85032-4

Reference yield: 82.0%

[1-14C]acetyl chloride (676-77-7) + (R)-4-(1-methylethyl)-5,5-diphenyl-1,3-oxazolidin-2-one (191090-32-1) → C19(14)CH21NO3

Guidance literature:

(R)-4-(1-methylethyl)-5,5-diphenyl-1,3-oxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; at 0 ℃;

[1-¹⁴C]acetyl chloride; In tetrahydrofuran; at 20 ℃; for 3h;

upstream raw materials:

[1-14C]acetic acid sodium salt

Refernces

• 1、 Lee, Helen T.,Woo, Peter W. K.. "Atorvastatin, an HMG-CoA reductase inhibitor and effective lipid-regulating agent. Part II: Synthesis of side-chain-labeled [14C]atorvastatin". . p. 129 - 133. Retrieved 2007/10/03.
• 2、 Kupczyk-Subotkowska, Lidia,Saunders Jr., William H.,Shine, Henry J.,Subotkowski, Witold. "Carbon kinetic isotope effects and transition structures in the rearrangements of allyl vinyl ethers. 2-(trimethylsiloxy)- and 2-(methoxycarbonyl)-3-oxa-1,5-hexadiene". . p. 7088 - 7093. Retrieved 2007/10/02.