3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene

Base Information

• Chemical Name: 3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene
• CAS No.: 1393444-78-4
• Molecular Formula: C₂₁H₂₂S
• Molecular Weight: 306.472
• Mol file: 1393444-78-4.mol

Synonyms:3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene

Chemical Property of 3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene

There total 3 articles about 3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-benzylthiophene (27921-48-8) + 1-bromo-4-tert-butylbenzene (3972-65-4) → 3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene (1393444-78-4)

Guidance literature:

With KN(SiMe₃)2; palladium diacetate; nixantphos; In cyclopentyl methyl ether; at 24 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja3047816

Reference yield: 42.0%

1-bromo-4-tert-butylbenzene (3972-65-4) + C18H16N2O2S2 (1428362-13-3) → 3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene (1393444-78-4)

Guidance literature:

With [1,1′-biphenyl]-2-yldiphenylphosphane; ammonium acetate; ammonium formate; palladium diacetate; caesium carbonate; In tert-Amyl alcohol; at 90 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol400690t

Reference yield:

3-benzoylthiophene (6453-99-2) → 3-((4-(tert-butyl)phenyl)(phenyl)methyl)thiophene (1393444-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / ethanol / 5 h / Reflux

2: palladium diacetate; caesium carbonate; [1,1′-biphenyl]-2-yldiphenylphosphane; ammonium acetate; ammonium formate / tert-Amyl alcohol / 4 h / 90 °C / Inert atmosphere; Schlenk technique

With [1,1′-biphenyl]-2-yldiphenylphosphane; ammonium acetate; ammonium formate; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; In tert-Amyl alcohol; ethanol;

DOI:10.1055/s-0036-1588893

upstream raw materials:

3-benzylthiophene

1-bromo-4-tert-butylbenzene

C₁₈H₁₆N₂O₂S₂

3-benzoylthiophene

Refernces

• 1、 Xia, Ying,Hu, Fangdong,Liu, Zhenxing,Qu, Peiyuan,Ge, Rui,Ma, Chen,Zhang, Yan,Wang, Jianbo. "Palladium-catalyzed diarylmethyl C(sp3)-C(sp2) bond formation: A new coupling approach toward triarylmethanes". supporting information. p. 1784 - 1787. Retrieved 2013/06/26.