2-Chloro-4-methylthiazole-5-sulfonamide

Base Information

• Chemical Name: 2-Chloro-4-methylthiazole-5-sulfonamide
• CAS No.: 348086-67-9
• Molecular Formula: C₄H₅ClN₂O₂S₂
• Molecular Weight: 212.681
• Hs Code.: 2935009090
• European Community (EC) Number: 846-534-5
• DSSTox Substance ID: DTXSID20477437
• Wikidata: Q72455328
• Mol file: 348086-67-9.mol

Synonyms:2-Chloro-4-methylthiazole-5-sulfonamide;348086-67-9;2-CHLORO-4-METHYL-THIAZOLE-5-SULFONIC ACID AMIDE;2-Chloro-4-methyl-1,3-thiazole-5-sulfonamide;C4H5ClN2O2S2;MFCD06658400;2-Chloro-4-methylthiazole-5-sulfonic acid amide;SCHEMBL1177539;DTXSID20477437;DJJSIXFBKIFPGR-UHFFFAOYSA-N;AKOS009491814;SB36758;BS-50447;SY198185;CS-0342823;FT-0659512;2-Chloro-4-methyl-1,3-thiazol-5-sulphonamide;EN300-204349;2-Chloro-4-methyl-1,3-thiazole-5-sulphonamide;A822411;J-508772

Chemical Property of 2-Chloro-4-methylthiazole-5-sulfonamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 361.1 °C at 760 mmHg
• Flash Point: 172.2 °C
• PSA: 109.67000
• Density: 1.568 g/cm³
• LogP: 2.53340
• Storage Temp.: 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 211.9480974
• Heavy Atom Count: 11
• Complexity: 237

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-4-methylthiazole-5-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(SC(=N1)Cl)S(=O)(=O)N

Technology Process of 2-Chloro-4-methylthiazole-5-sulfonamide

There total 2 articles about 2-Chloro-4-methylthiazole-5-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 2-chloro-4-methyl-1,3-thiazole-5-sulphonamide (348086-67-9)

Guidance literature:

Reference yield:

2-chloro-4-methylthiazole-5-sulfonyl chloride (292138-59-1) → 2-chloro-4-methyl-1,3-thiazole-5-sulphonamide (348086-67-9)

Guidance literature:

With ammonia; In tetrahydrofuran; water; at -10 ℃; for 2h;

Reference yield: 92.35%

2-chloro-4-methyl-1,3-thiazole-5-sulphonamide (348086-67-9) + methylamine (74-89-5) → 4-methyl-2-(methylamino)-1,3-thiazole-5-sulfonamide (348086-68-0)

Guidance literature:

In tetrahydrofuran; water; at 50 ℃; for 4h;

upstream raw materials:

2-chloro-4-methylthiazole-5-sulfonyl chloride

Downstream raw materials:

4-methyl-2-(methylamino)-1,3-thiazole-5-sulfonamide

Refernces

• 1、 Carta, Fabrizio,Birkmann, Alexander,Pfaff, Tamara,Buschmann, Helmut,Schwab, Wilfried,Zimmermann, Holger,Maresca, Alfonso,Supuran, Claudiu T.. "Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action". . p. 3154 - 3164. Retrieved 2017/04/19.
• 2、 -. "Acetylenyl-pyrazolo-pyrimidine derivatives". Page/Page column 29. . Retrieved 2008/06/13.