(4-BENZYL-MORPHOLIN-2-YLMETHYL)-METHYL-AMINE

Base Information

• Chemical Name: (4-BENZYL-MORPHOLIN-2-YLMETHYL)-METHYL-AMINE
• CAS No.: 126645-75-8
• Molecular Formula: C13H20 N2 O
• Molecular Weight: 220.31
• Hs Code.: 2934999090
• Mol file: 126645-75-8.mol

Synonyms:(4-BENZYL-MORPHOLIN-2-YLMETHYL)-METHYL-AMINE;(4-BENZYLMORPHOLIN-2-YL)-N-METHYL METHANAMINE

Chemical Property of (4-BENZYL-MORPHOLIN-2-YLMETHYL)-METHYL-AMINE

Chemical Property:

• PSA: 24.50000
• LogP: 1.43560
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

N-Methyl-4-benzyl-2-morpholinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-BENZYL-MORPHOLIN-2-YLMETHYL)-METHYL-AMINE

There total 5 articles about (4-BENZYL-MORPHOLIN-2-YLMETHYL)-METHYL-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-<(N-acetyl-N-methylamino)methyl>-4-benzylmorpholine (126645-74-7) → 4-benzyl-2-<(methylamino)methyl>morpholine (126645-75-8)

Guidance literature:

With hydrogenchloride; for 16h; Heating;

DOI:10.1021/jm00167a020

Reference yield:

N-benzyl-2-chloromethylmorpholine (40987-25-5,186293-54-9) + methylamine (74-89-5) → 4-benzyl-2-<(methylamino)methyl>morpholine (126645-75-8)

Guidance literature:

In ethanol; at 110 ℃;

Reference yield:

4-benzyl-2-cyanomorpholine (147767-51-9,126645-52-1) → 4-benzyl-2-<(methylamino)methyl>morpholine (126645-75-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) H₂, acetic acid / 1.) Raney nickel / 1.) 95 percent EtOH, RT, 2.) CHCl₃, RT, 2 h

2: 1.) NaH / 1.) THF, RT, 1 h, 2.) RT, 4 h

3: 89 percent / 10percent HCl / 16 h / Heating

With hydrogenchloride; hydrogen; sodium hydride; acetic acid; nickel;

DOI:10.1021/jm00167a020

upstream raw materials:

2-<(N-acetyl-N-methylamino)methyl>-4-benzylmorpholine

4-benzyl-2-cyanomorpholine

2-(N-acetylaminomethyl)-4-benzylmorpholine

N-benzyl-2-chloromethylmorpholine

Downstream raw materials:

5-amino-N-<(4-benzyl-2-morpholinyl)methyl>-5-chloro-2-methoxy-N-methylbenzamide

Refernces

• 1、 -. "Inhibition of FGFR3 and treatment of multiple myeloma". . . Retrieved 2008/06/13.
• 2、 Kato,Morie,Hino,Kon,Naruto,Yoshida,Karasawa,Matsumoto. "Novel benzamides as selective and potent gastric prokinetic agents. 1. Synthesis and structure-activity relationships of N-[(2-morpholinyl)alkyl]benzamides". . p. 1406 - 1413. Retrieved 2007/10/02.