AG 1478

Base Information

• Chemical Name: AG 1478
• CAS No.: 175178-82-2
• Molecular Formula: C16H14ClN3O2
• Molecular Weight: 315.75
• Mol file: 175178-82-2.mol

Synonyms:4-(3-Chloro-benzyl)-6,7-dimethoxy-quinazoline;

Chemical Property of AG 1478

Chemical Property:

• Boiling Point: 458.465 °C at 760 mmHg
• Flash Point: 231.072 °C
• PSA: 56.27000
• Density: 1.338 g/cm³
• LogP: 4.11700
• Storage Temp.: 2-8°C
• Solubility.: 0.1 M HCl: soluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tyrphostin AG 1478 ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines.1,2 AG-1478 reduces pulmonary fibrosis in a rat model.3?Cell permeable.
• Uses: Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431. Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.