4-(2-hydroxyethoxy)benzoic Acid

Base Information

• Chemical Name: 4-(2-hydroxyethoxy)benzoic Acid
• CAS No.: 1711-24-6
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID00401831
• Nikkaji Number: J62.064E
• Wikidata: Q82205089
• Mol file: 1711-24-6.mol

Synonyms:4-(2-hydroxyethoxy)benzoic Acid;1711-24-6;4-(2-Hydroxy-ethoxy)-benzoic acid;4-(2-hydroxyethoxy)benzenecarboxylic acid;4-(hydroxyethoxy)benzoic acid;4-(2-Hydroxyethoxy)benzoicacid;Benzoic acid,4-(2-hydroxyethoxy)-;4-(2-HYDROXY-ETHOXY)-BENZOICACID;Oprea1_198308;SCHEMBL77587;DTXSID00401831;p-(2-hydroxyethoxy)-benzoic acid;QLIQIXIBZLTPGQ-UHFFFAOYSA-N;4-(2-hydroxyethyloxy)benzoic acid;BAA71124;MFCD00020367;AKOS000182890;CS-0157426;FT-0680078;EN300-75227;D94910;12N-142;A881952;J-513306;Z118461560

Chemical Property of 4-(2-hydroxyethoxy)benzoic Acid

Chemical Property:

• Vapor Pressure: 3.5E-06mmHg at 25°C
• Melting Point: 177-179 °C
• Refractive Index: 1.571
• Boiling Point: 371.7 °C at 760 mmHg
• PKA: 4.40±0.10(Predicted)
• Flash Point: 153.2 °C
• PSA: 66.76000
• Density: 1.301 g/cm³
• LogP: 0.75590
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 161

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Hydroxyethoxy)benzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)O)OCCO

Technology Process of 4-(2-hydroxyethoxy)benzoic Acid

There total 15 articles about 4-(2-hydroxyethoxy)benzoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Bromobenzoic acid (586-76-5) + ethylene glycol (107-21-1) → 4-(2-hydroxyethoxy)benzoic acid (1711-24-6)

Guidance literature:

With potassium carbonate; copper dichloride; at 130 ℃; for 20h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4ob00649f

Reference yield: 85.0%

2-chloro-ethanol (107-07-3) + 4-hydroxy-benzoic acid (99-96-7) → 4-(2-hydroxyethoxy)benzoic acid (1711-24-6)

Guidance literature:

With potassium iodide; sodium hydroxide; In ethanol; water; at 70 ℃; for 24h; Reagent/catalyst;

Reference yield: 81.0%

2-bromoethanol (540-51-2) + 4-hydroxy-benzoic acid (99-96-7) → 4-(2-hydroxyethoxy)benzoic acid (1711-24-6)

Guidance literature:

With potassium iodide; potassium hydroxide; In water; at 110 ℃; for 24h; Reflux;

DOI:10.1039/c4ta06347c

upstream raw materials:

oxirane

methyl 4-hydroxylbenzoate

4-(2-hydroxyethoxy)benzoic acid methyl ester

2-chloro-ethanol

Downstream raw materials:

4-(2-chloro-ethoxy)-benzoyl chloride

4-(2-hydroxyethoxy)cyclohexanecarboxylic acid

4-(2-undec-10-enoyloxyethoxy)benzoic acid

4-hydroxybiphenyl-4'-(2-undec-10-enoyloxyethoxy)benzoate

Refernces

• 1、 -. "A biphenyl type acrylate liquid crystal resin synthesis method". Paragraph 0028; 0030; 0040; 0042. . Retrieved 2019/02/02.
• 2、 Gao, Yanzi,Yao, Wenhuan,Sun, Jian,Zhang, Huimin,Wang, Zhendong,Wang, Ling,Yang, Dengke,Zhang, Lanying,Yang, Huai. "A novel soft matter composite material for energy-saving smart windows: From preparation to device application". supporting information. p. 10738 - 10746. Retrieved 2015/05/27.