(S)-(-)-2-PHENYL-1-PROPANOL

Base Information

• Chemical Name: (S)-(-)-2-PHENYL-1-PROPANOL
• CAS No.: 37778-99-7
• Molecular Formula: C9H12O
• Molecular Weight: 136.194
• Hs Code.: 29062900
• Mol file: 37778-99-7.mol

Synonyms:Benzeneethanol,b-methyl-, (S)-;(-)-2-Phenyl-1-propanol;(-)-2-Phenylpropanol;(-)-b-Methylbenzeneethanol;(2S)-2-Phenylpropan-1-ol;(S)-(-)-2-Phenylpropyl alcohol;(S)-2-Phenyl-1-propanol;2(S)-Phenyl-1-propanol;S-(-)-2-Phenyl-1-propanol;

Chemical Property of (S)-(-)-2-PHENYL-1-PROPANOL

Chemical Property:

• Appearance/Colour: Clear colourless liquid
• Refractive Index: n20/D 1.526(lit.)
• Boiling Point: 232.22 °C at 760 mmHg
• PKA: 14.79±0.10(Predicted)
• Flash Point: 77.407 °C
• PSA: 20.23000
• Density: 0.994 g/cm³
• LogP: 1.78240
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(S)-2-Phenyl-1-propanol purum, ≥98.0% (sum of enantiomers, GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-(-)-2-PHENYL-1-PROPANOL

There total 297 articles about (S)-(-)-2-PHENYL-1-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(R)-2-phenylpropionic acid-(R)-1-phenylethyl ester (79121-13-4) → (R)-1-phenylethanol (1517-69-7) + (+)-(R)-2-phenylpropanol (1123-85-9,37778-99-7,98103-87-8,19141-40-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1055/s-2008-1032068

Reference yield: 75.0%

methyllithium (917-54-4) + (S)-styrene oxide (20780-54-5) → 1-Phenyl-1-propanol (93-54-9) + (+)-(R)-2-phenylpropanol (1123-85-9,37778-99-7,98103-87-8,19141-40-3)

Guidance literature:

With boron trifluoride diethyl etherate; In tetrahydrofuran; for 0.25h;

DOI:10.1016/S0957-4166(98)00160-8

Reference yield: 30.0%

bromobenzene (108-86-1,52753-63-6) + (R)-propylene oxide (15448-47-2) → (S)-2-phenyl-1-propanol (37778-99-7) + (+)-(R)-2-phenylpropanol (1123-85-9,37778-99-7,98103-87-8,19141-40-3) + (R)-1-phenyl-propan-2-ol (1572-95-8,14898-87-4)

Guidance literature:

With [2,2]bipyridinyl; manganese; (1,2-dimethoxyethane)dichloronickel(II); bis(η5((1R,2S,5R)-5-methyl-2-[prop-2-yl]-cyclohex-1-yl)cyclopentadienyl)-titanium dichloride; sodium thiophenolate; triethylamine hydrochloride; In benzene; at 20 ℃; for 4h; enantioselective reaction; Inert atmosphere; Glovebox; Autoclave;

DOI:10.1021/jacs.5b01909

upstream raw materials:

(RS)-2-phenyl-1-propanol

(2S)-2-phenylpropionyl chloride

vinyl acetate

2-phenyl-1-propyl butyrate

Downstream raw materials:

(S)-1-phenylpropan-2-ol

(S)-2-Phenylpropionic acid

(R)-2-Phenylpropionic acid

Refernces

• 1、 Mori, Seiji,Ojima, Kohei,Oriyama, Takeshi,Sakai, Naoki. "Integrated Experimental and Computational Studies on the Organocatalytic Kinetic Resolution of β-Unfunctionalized Primary Alcohols Using a Chiral 1,2-Diamine: The Importance of Noncovalent Interactions". supporting information. p. 4468 - 4475. Retrieved 2022/03/14.
• 2、 Gavin, Declan P.,Murphy, Edel J.,Foley, Aoife M.,Castilla, Ignacio Abreu,Reen, F. Jerry,Woods, David F.,Collins, Stuart G.,O'Gara, Fergal,Maguire, Anita R.. "Identification of an Esterase Isolated Using Metagenomic Technology which Displays an Unusual Substrate Scope and its Characterisation as an Enantioselective Biocatalyst". . p. 2466 - 2474. Retrieved 2019/03/11.