N-hydroxysuccinimide folate

Base Information

• Chemical Name: N-hydroxysuccinimide folate
• CAS No.: 153445-05-7
• Molecular Formula: C₂₃H₂₂N₈O₈
• Molecular Weight: 538.476
• Mol file: 153445-05-7.mol

Synonyms:N-hydroxysuccinimide folate

Chemical Property of N-hydroxysuccinimide folate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxysuccinimide folate

There total 11 articles about N-hydroxysuccinimide folate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + folate (59-30-3) → N-hydroxysuccinimide folate (153445-05-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 20 ℃; for 24h; Darkness;

DOI:10.1016/j.carbpol.2012.08.112

Reference yield: 85.0%

folic acid (59-30-3) + 1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) → folic acid, N-hydroxysuccinimide ester (153445-05-7)

Guidance literature:

folic acid; With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Darkness;

1-hydroxy-pyrrolidine-2,5-dione; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Darkness;

Reference yield: 60.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + (S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)pentanedioic acid (59-30-3) → (S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)-5-((2,5-dioxopyrrolidin-1-yl)oxy)-5-oxopentanoic acid (153445-05-7)

Guidance literature:

(S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)pentanedioic acid; With dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 20 ℃; for 2h;

1-hydroxy-pyrrolidine-2,5-dione; With dmap; In dimethyl sulfoxide; at 40 ℃; Inert atmosphere; Darkness;

DOI:10.1021/bm900853z

upstream raw materials:

folic acid

1-hydroxy-pyrrolidine-2,5-dione

folate

dicyclohexyl-carbodiimide

Downstream raw materials:

folate-γ-ethylenediamine

C₃₄H₄₉N₉O₁₀

C₇₃H₇₉N₉O₂₃S₂

C₄₅H₄₇N₁₉O₁₂S₂

Refernces

• 1、 Zhang, Jian,Deng, Dawei,Qian, Zhiyu,Liu, Fei,Chen, Xinyang,An, Lianxiao,Gu, Yueqing. "The targeting behavior of folate-nanohydrogel evaluated by near infrared imaging system in tumor-bearing mouse model". . p. 46 - 55. Retrieved 2010.
• 2、 Yang, Mengqian,Deng, Jingran,Guo, Ding,Zhang, Jie,Yang, Lixia,Wu, Fengshou. "A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy". . p. 5367 - 5374. Retrieved 2019.
• 3、 Cheng, Hongbo,Guo, Shuang,Cui, Zhixiang,Zhang, Xin,Huo, Yingnan,Guan, Jian,Mao, Shirui. "Design of folic acid decorated virus-mimicking nanoparticles for enhanced oral insulin delivery". . . Retrieved 2021.
• 4、 Chen, Juan,Corbin, Ian R.,Li, Hui,Cao, Weiguo,Glickson, Jerry D.,Zheng, Gang. "Ligand conjugated low-density lipoprotein nanoparticles for enhanced optical cancer imaging in vivo". . p. 5798 - 5799. Retrieved 2007.
• 5、 Wang, Zhongling,Zhu, Jing,Chen, Yinyin,Geng, Kaiming,Qian, Nong,Cheng, Liang,Lu, Ziwei,Pan, Yue,Guo, Liang,Li, Yonggang,Gu, Hongwei. "Folic acid modified superparamagnetic iron oxide nanocomposites for targeted hepatic carcinoma MR imaging". . p. 7483 - 7490. Retrieved 2014.
• 6、 Guo, Xing,Shi, Chunli,Yang, Guang,Wang, Jie,Cai, Zhenghong,Zhou, Shaobing. "Dual-responsive polymer micelles for target-cell-specific anticancer drug delivery". . p. 4405 - 4418. Retrieved 2014.
• 7、 Novo, Luiìs,Mastrobattista, Enrico,Van Nostrum, Cornelus F.,Hennink, Wim E.. "Targeted decationized polyplexes for cell specific gene delivery". . p. 802 - 812. Retrieved 2014.
• 8、 Rahnel, Hedi,Viht, Kaido,Lavogina, Darja,Mazina, Olga,Haljasorg, T?iv,Enkvist, Erki,Uri, Asko. "A Selective Biligand Inhibitor of CK2 Increases Caspase-3 Activity in Cancer Cells and Inhibits Platelet Aggregation". . p. 1723 - 1736. Retrieved 2017.
• 9、 Qu, Ding,Lin, Haijiao,Zhang, Nan,Xue, Jingwei,Zhang, Can. "In vitro evaluation on novel modified chitosan for targeted antitumor drug delivery". . p. 545 - 554. Retrieved 2013.
• 10、 Li, Li,Bae, Byoung-Chan,Tran, Thanh Huyen,Yoon, Kwon Hyeok,Na, Kun,Huh, Kang Moo. "Self-quenchable biofunctional nanoparticles of heparin-folate- photosensitizer conjugates for photodynamic therapy". . p. 708 - 715. Retrieved 2011.