N-benzyl-5H-dibenzoazepine

Base Information

• Chemical Name: N-benzyl-5H-dibenzoazepine
• CAS No.: 78943-58-5
• Molecular Formula: C₂₁H₁₇N
• Molecular Weight: 283.373
• Mol file: 78943-58-5.mol

Synonyms:N-benzyl-5H-dibenzoazepine

Chemical Property of N-benzyl-5H-dibenzoazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-5H-dibenzoazepine

There total 14 articles about N-benzyl-5H-dibenzoazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dibenzoazepine (256-96-2) + benzyl bromide (100-39-0) → N-benzyl-5H-dibenzoazepine (78943-58-5)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; for 48h;

DOI:10.1002/jhet.5570190667

Reference yield: 99.0%

(Z)-2,2'-dibromostilbene (56667-12-0,108474-32-4,56667-11-9) + benzylamine (100-46-9) → N-benzyl-5H-dibenzoazepine (78943-58-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; bis[2-(diphenylphosphino)phenyl] ether; In toluene; at 120 ℃; for 9h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.09.042

Reference yield: 90.1%

5H-N-benzyl-10,11-dihydrobenzazepin-10-one (10464-31-0) → N-benzyl-5H-dibenzoazepine (78943-58-5)

Guidance literature:

With methanol; sodium tetrahydroborate; at 40 - 45 ℃; for 4h;

upstream raw materials:

dibenzoazepine

benzyl bromide

benzyl chloride

iminostilbene nitranion

Downstream raw materials:

dibenzoazepine

9-methyl-acridine

pyrrolo<3,2,1-jk>carbazole

1,1'-(1,2-ethanediyl)bisbenzene

Refernces

• 1、 Gini, Andrea,Manche?o, Olga García. "Mild Radical Oxidative sp3-Carbon-Hydrogen Functionalization: Innovative Construction of Isoxazoline and Dibenz[ b, f ]oxepine/azepine Derivatives". . p. 526 - 539. Retrieved 2016/03/12.
• 2、 Tian, Maoqun,Abdelrahman, Aliaa,Weinhausen, Stephanie,Hinz, Sonja,Weyer, Stefanie,Dosa, Stefan,El-Tayeb, Ali,Müller, Christa E.. "Carbamazepine derivatives with P2X4 receptor-blocking activity". supporting information. p. 1077 - 1088. Retrieved 2014/02/14.