10-Hydroxycamptothecin

Base Information

• Chemical Name: 10-Hydroxycamptothecin
• CAS No.: 130194-92-2
• Molecular Formula: C₂₀H₁₆N₂O₅
• Molecular Weight: 364.357
• Hs Code.: 2942000000
• Mol file: 130194-92-2.mol

Synonyms:CAMPTOTHECIN, 10-HYDROXY-;CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA;HCPT;HYDROXYCAMPTOTHECIN;HYDROXYCAMPTOTHECIN, 10-;SN38;1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione, 4-ethyl-4,10-dihydroxy-

Chemical Property of 10-Hydroxycamptothecin

Chemical Property:

• Refractive Index: 1.776
• Boiling Point: 820.7oC at 760mmHg
• Flash Point: 450.1oC
• PSA: 101.65000
• Density: 1.60
• LogP: 1.78520

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10-Hydroxycamptothecin

There total 16 articles about 10-Hydroxycamptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.2%

Camptothecin 1-oxide (86639-48-7) → 10-hydroxycamptothecin (67656-30-8,130194-92-2)

Guidance literature:

With sulfuric acid; In dioxane-acetonitrile-water;

Reference yield: 88.0%

→ 10-hydroxycamptothecin (67656-30-8,130194-92-2)

Guidance literature:

Reference yield: 68.0%

9-methoxycamptothecin (39026-92-1) → 10-hydroxycamptothecin (67656-30-8,130194-92-2)

Guidance literature:

With hydrogen bromide; at 110 ℃; for 24h; Sealed tube;

upstream raw materials:

9-amino-20(S)-camptothecin

rubitecan

camptothecin

2,6-dinitrobenzaldehyde

Refernces

• 1、 -. "Preparation of 9-fluorocamptothecin derivative and application of 9-fluorocamptothecin derivative in antitumor aspect". Paragraph 0014-0018. . Retrieved 2022/01/12.
• 2、 Gao, Mingzhang,Miller, Kathy D.,Sledge, George W.,Zheng, Qi-Huang. "Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers". . p. 3865 - 3869. Retrieved 2007/10/03.