4,4'-Diphenylmethane diisocyanate

Base Information Edit

Chemical Name:4,4'-Diphenylmethane diisocyanate
CAS No.:25686-28-6
Deprecated CAS:142690-07-1,153986-89-1,201528-77-0,53633-14-0,55157-41-0,57460-66-9,77090-48-3,88001-94-9,97568-33-7,1211266-59-9,1211316-64-1,1220313-65-4,1400594-70-8,1533423-48-1,1588489-56-8,2031250-39-0,2056146-02-0,12125-47-2,156580-59-5,28515-38-0,65916-89-4,327155-87-3,10031-75-1,1211266-59-9,1211316-64-1,1220313-65-4,1400594-70-8,1533423-48-1,153986-89-1,1588489-56-8,201528-77-0,2031250-39-0,2056146-02-0,53633-14-0,55157-41-0,57460-66-9,77090-48-3,97568-33-7
Molecular Formula:C₁₅H₁₀N₂O₂
Molecular Weight:250.257
Hs Code.:
European Community (EC) Number:202-966-0,500-040-3,247-714-0
ICSC Number:0298
NSC Number:9596
UN Number:2206,2489
UNII:B0LO6BBS8C
DSSTox Substance ID:DTXSID7025180
Nikkaji Number:J3.231J
Wikipedia:Methylene_diphenyl_diisocyanate
Wikidata:Q417646
Metabolomics Workbench ID:58595
ChEMBL ID:CHEMBL1488467
Mol file:25686-28-6.mol

Synonyms:1,1'-methylenebis(4-isocyanatobenzene);1,1-methylenebis(phenyl)diisocyanate;4,4'-diisocyanatodiphenylmethane;4,4'-diphenylmethane diisocyanate;4,4'-methylene bisphenyl diisocyanate;4,4'-methylenebis(phenylisocyanate);4,4'-methylenediphenyl diisocyanate;diphenylmethane diisocyanate;diphenylmethane-4,4'-diisocyanate;methylene diphenyl diisocyanate;methylenebis(phenyl isocyanate);p,p'-diphenylmethane diisocyanate

Suppliers and Price of 4,4'-Diphenylmethane diisocyanate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 23 raw suppliers

Chemical Property of 4,4'-Diphenylmethane diisocyanate Edit

Chemical Property:

Vapor Pressure:0.001Pa at 20℃
Water Solubility.:30μg/L at 22℃
XLogP3:5.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:250.074227566
Heavy Atom Count:19
Complexity:332
Transport DOT Label:Poison

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: Total 1 MSDS from other Authors

Useful:

Chemical Classes:Plastics & Rubber -> Diisocyanates,Plastics & Rubber -> Polymers
Canonical SMILES:C1=CC(=CC=C1CC2=CC=C(C=C2)N=C=O)N=C=O
Recent ClinicalTrials:Pilot Study of Ensifentrine or Placebo Delivered Via pMDI in Hospitalized Patients With COVID-19
Inhalation Risk:Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
Effects of Short Term Exposure:Lachrymation. The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the lungs. This may result in impaired functions.
Effects of Long Term Exposure:Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.

Technology Process of 4,4'-Diphenylmethane diisocyanate

There total 67 articles about 4,4'-Diphenylmethane diisocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

: 4,4'-methylenediphenyl dicarbamate

: 101-68-8,25686-28-6,97568-33-7
di(4-isocyanatophenyl)methane

Guidance literature:: With copper; In para-xylene; at 220 ℃; for 2h; under 2625.26 Torr; Reagent/catalyst; Pressure; Temperature; Solvent;

Reference yield: 96.0%

: 7450-63-7
dimethyl 4,4'-methylenebis(1,4-phenylene)diurethane

: 101-68-8,25686-28-6,97568-33-7
di(4-isocyanatophenyl)methane

Guidance literature:: With zinc diacetate; 1-((ethoxycarbonyl)methyl)-3-methylimidazolium tetrafluoroborate; In neat (no solvent); at 25 - 230 ℃; for 0.25h; Reagent/catalyst; Solvent; Catalytic behavior; Mechanism; Inert atmosphere;
DOI:10.1039/c8nj01175c